Development of Colorimetric Indicators: A New Technique to Determine Glutaraldehyde and Alkaline Glutaraldehyde Contamination

Details

• Personal Author:
  Vo E
• Description:
  The aim of the study was to develop a new indicator sensor pad for detection of glutaraldehyde permeation of chemical protective gloves. The pad carries a reagent which responds to glutaraldehyde contaminant by producing a color change. Some commonly used glutaraldehyde and alkaline glutaraldehyde solutions, Metricide, Cetylcide-G, and 50% glutaraldehyde solution, were analyzed by solvent desorption and gas chromatography. All glutaraldehyde solutions exhibited >98% adsorption on the pads over the spiking range 0.05-5.0 µL. Recovery for each glutaraldehyde solution was calculated, ranging from 58-92% (RSD =4.0%) for all glutaraldehyde solutions. Breakthrough times for two protective glove materials (PVC and polymerized alkene) were determined using the Thermo-Hand Method, and found to range from 76 to 150 min for Metricide, from 170 to 230 min for Cetylcide-G, and from 232 to 300 min for 50% glutaraldehyde. The quantitative mass of the glutaraldehyde solutions on the pads at the time of breakthrough detection ranged from 35-37, 37-39, and 38-40 µg/cm² for Metricide, Cetylcide-G, and 50% glutaraldehyde, respectively. The new aldehyde indicator pad should find utility in detecting, collecting, and quantitative analyzing glutaraldehyde and alkaline glutaraldehyde permeation samples in the workplace. [Description provided by NIOSH]
• Subjects:
  Occupational Health Personal Protective Equipment Protective Clothing Safety Solvents
• Keywords:
  Gas-chromatography Gloves Personal-protection Personal-protective-equipment Protective-clothing Protective-equipment Quantitative-analysis
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  District of Columbia ; OSHA Region 3 ; Pennsylvania ; Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  NPPTL - National Personal Protective Technology Laboratory
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20023199
• Citation:
  International conference on occupational and environmental exposures of skin to chemicals: science and policy, September 8-11, 2002, Washington, DC. Morgantown, WV: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 2002 Sep; :165
• CAS Registry Number:
  Glutaraldehyde (CAS RN 111-30-8)
• Federal Fiscal Year:
  2002
• NORA Priority Area:
  Disease and Injury: Allergic and Irritant Dermatitis ; Research Tools and Approaches: Control Technology and Personal Protective Equipment
• Peer Reviewed:
  False
• Source Full Name:
  International conference on occupational and environmental exposures of skin to chemicals: science and policy, September 8-11, 2002, Washington, DC
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1849f21fd2287769ef0dc719ea30ad7c820108fd026f988ba3b01af99787d9a0667d7c0a5efb29dcd238e2411936c8c2e030a823d960c712a08c421481095fd1
• Download URL:
  https://stacks.cdc.gov/view/cdc/195753/cdc_195753_DS1.pdf
• File Type:
  [PDF - 957.75 KB ]