A novel system to generate WTC dust particles for inhalation exposures

Details

• Personal Author:
  Asgharian B ; Chen L-C ; Cohen MD ; Garrett BJ ; Ghio A ; Horton L ; Peltier RE ; Prophete C ; Sisco M ; Soukup JM ; Vaughan JM ; Zelikoff JT
• Description:
  First responders (FRs) present at Ground Zero within the critical first 72 h after the World Trade Center (WTC) collapse have progressively exhibited significant respiratory injury. The majority (>96%) of WTC dusts were >10 µm and no studies have examined potential health effects of this size fraction. This study sought to develop a system to generate and deliver supercoarse (10-53 µm) WTC particles to a rat model in a manner that mimicked FR exposure scenarios. A modified Fishing Line generator was integrated onto an intratracheal inhalation (ITIH) system that allowed for a bypassing of the nasal passages so as to mimic FR exposures. Dust concentrations were measured gravimetrically; particle size distribution was measured via elutriation. Results indicate that the system could produce dusts with 23 µm mass median aerodynamic diameter (MMAD) at levels up to >/=1200 mg/m3. To validate system utility, F344 rats were exposed for 2 h to approximate 100 mg WTC dust/m3. Exposed rats had significantly increased lung weight and levels of select tracer metals 1 h after exposure. Using this system, it is now possible to conduct relevant inhalation exposures to determine adverse WTC dusts impacts on the respiratory system. Furthermore, this novel integrated Fishing Line-ITIH system could potentially be used in the analyses of a wide spectrum of other dusts/pollutants of sizes previously untested or delivered to the lungs in ways that did not reflect realistic exposure scenarios. [Description provided by NIOSH]
• Subjects:
  Dust Emergencies Emergency Responders Laboratories Lung Lung Diseases Metals Nose Occupational Health Particulate Matter Respiratory System Respiratory Tract Diseases Safety Sense Organs September 11 Terrorist Attacks

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• Keywords:
  Analytical-instruments Analytical-models Author Keywords: World Trade Center Dust Dust-analysis Dust-exposure Dust-measurement Dust-particles Emergency-responders Emergency-response Exposure-levels Exposure-methods Fishing Line Generator Gravimetric-analysis Inhalation-studies Intratracheal Inhalation Laboratory-animals Laboratory-techniques Lung-disorders Nasal-cavity Particle-aerodynamics Particulate-dust Pulmonary-system-disorders Respiratory-system-disorders Trace-metals WTC

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• ISSN:
  1559-0631
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; New York ; North Carolina ; OSHA Region 1 ; OSHA Region 2 ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  105-112
• Volume:
  24
• Issue:
  1
• NIOSHTIC Number:
  nn:20043389
• Citation:
  J Expo Sci Environ Epidemiol 2014 Jan-Feb; 24(1):105-112
• Contact Point Address:
  Dr. Mitchell D. Cohen, Department of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
• Email:
  mitchell.cohen@nyumc.org
• Federal Fiscal Year:
  2014
• Performing Organization:
  New York University School of Medicine
• Peer Reviewed:
  True
• Start Date:
  20090701
• Source Full Name:
  Journal of Exposure Science and Environmental Epidemiology
• End Date:
  20140630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:45de0af188a2dd79cdefb041672ab6bd34ce52eb351e624bd15ecffaf741a6f693b32f736f4e1e78bb5534c80c3f8a38fb000c38d717e216496bb942e53e4de8
• Download URL:
  https://stacks.cdc.gov/view/cdc/195297/cdc_195297_DS1.pdf
• File Type:
  [PDF - 1.33 MB ]