Genetic variants within the MHC region are associated with immune responsiveness to childhood vaccinations

Details

• Personal Author:
  Barmada MM ; Biagini, Raymond E. ; Frye B ; Germolec DR ; Johnson VJ ; Luster MI ; Talzhanov Y ; Wang W ; Weissman, David N. ; Wilson NW ; Yucesoy, Berran
• Description:
  The influence of genetic variability within the major histocompatibility complex (MHC) region on variations in immune responses to childhood vaccination was investigated. The study group consisted of 135 healthy infants who had been immunized with hepatitis B (HBV), 7-valent pneumococcal conjugate (PCV7), and diphtheria, tetanus, acellular pertussis (DTaP) vaccines according to standard childhood immunization schedules. Genotype analysis was performed on genomic DNA using Illumina Goldengate MHC panels (Mapping and Exon Centric). At the 1 year post vaccination check-up total, isotypic, andantigen-specific serum antibody levels were measured using multiplex immunoassays. A number of single nucleotide polymorphisms (SNPs) within MHC Class I and II genes were found to be associated with variations in the vaccine specific antibody responses and serum levels of immunoglobulins (IgG, IgM) and IgG isotypes (IgG1, IgG4) (all at p < 0.001). Linkage disequilibrium patterns and functional annotations showed that significant SNPs were strongly correlated with other functional regulatory SNPs. These SNPs were found to regulate the expression of a group of genes involved in antigen processing and presentation including HLA-A, HLA-C, HLA-G, HLA-H, HLA-DRA, HLA-DRB1, HLA-DRB5, HLA-DQA1, HLA-DQB1, HLA-DOB, and TAP-2. The results suggest that genetic variations within particular MHC genes can influence immune response to common childhood vaccinations, which in turn may influence vaccine efficacy. [Description provided by NIOSH]
• Subjects:
  Antibodies Antigens Biological Assay Communicable Diseases Genetics Histology Immune System Nucleotides Occupational Health Safety
• Keywords:
  Antibody-response Author Keywords: Major Histocompatibility Complex Bioassays Blood-serum Childhood Vaccine Immune Response Children Genes Genetic-factors Genetic Polymorphism Hepatitis Immune-reaction Immunoglobulins Morphology Vaccines

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• ISSN:
  0264-410X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Nevada ; North Carolina ; Ohio ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 9 ; Pennsylvania ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; DART - Division of Applied Research and Technology ; DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  31
• Issue:
  46
• NIOSHTIC Number:
  nn:20043357
• Citation:
  Vaccine 2013 Nov; 31(46):5381-5391
• Contact Point Address:
  Berran Yucesoy, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA
• Email:
  byucesoy@cdc.gov
• Federal Fiscal Year:
  2014
• NORA Priority Area:
  Healthcare and Social Assistance ; Services
• Peer Reviewed:
  True
• Source Full Name:
  Vaccine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6ccc836b52785705da80631c7b2145056428bc85257819019a3c469b77bab5fa672d85c4ebb85d197f43ccdae814582c7ac1111461ac53cb1573e9eb885d58d9
• Download URL:
  https://stacks.cdc.gov/view/cdc/195275/cdc_195275_DS1.pdf
• File Type:
  [PDF - 359.88 KB ]