Laboratory studies of the impact of calcite on in vitro and in vivo effects of coal dust: a potential preventive agent for coal workers' pneumoconiosis

Details

• Personal Author:
  Aladdin M ; Chen L-C ; Finkelman RB ; Huang X ; Jian J ; Yang Q
• Description:
  Background: Bioavailable iron (BAI) in coal, which may play a key role in causing coal workers' pneumoconiosis (CWP), is present at relatively high levels in Appalachian coals. Calcite decreases BAI and is more plentiful in Western coals than in Appalachian coals, possibly explaining the lower CWP prevalence among Western miners. Methods: We measured effects of calcite on BAI in non-cellular and cellular systems involving Pennsylvania (PA) coal dust. We also tested in vivo effects of calcite on transferrin receptor and markers of epithelial mesenchymal transition (EMT) and inflammation in mice exposed to PA coal. Results: Calcite rapidly eliminated BAI in an aqueous suspension of PA coal. Ferritin induction in human lung epithelial cells exposed to PA coal was effectively eliminated by calcite. Mouse lung tissue markers indicated increased EMT after exposure to PA coal dust, but not after exposure to PA coal plus calcite. Markers of inflammation increased following exposure to PA coal alone, but not following exposure to PA coal plus calcite. Conclusion: Additional research may lead to the use of supplemental calcite in coal mining as a safe and effective way to prevent CWP among Appalachian coal miners. [Description provided by NIOSH]
• Subjects:
  Biomarkers Calcium Compounds Coal Coal Mining Dust Ferrous Compounds Immune System Laboratories Lung Lung Diseases Mining Occupational Health Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Author Keywords: Iron Calcium Calcium-compounds Coal-dust Coal-miners Coal-mining Coal-workers-pneumoconiosis Coal Workers' Pneumoconiosis (CWP) Disease-prevention Epithelial Mesenchymal Transition (EMT) Fibrosis Immune-reaction In-vitro-study In-vivo-study Iron-compounds Laboratory-animals Laboratory-testing Lung-cells Lung-disease Lung-fibrosis Mining-industry Pulmonary-system-disorders Respiratory-system-disorders

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• ISSN:
  0271-3586
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  292-299
• Volume:
  56
• Issue:
  3
• NIOSHTIC Number:
  nn:20042993
• Citation:
  Am J Ind Med 2013 Mar; 56(3):292-299
• Contact Point Address:
  Xi Huang, PhD, New York University School of Medicine, Hospital for Joint Diseases, Room1600, 550 First Avenue, NewYork, NY 10016
• Email:
  xi.huang@nyumc.org
• CAS Registry Number:
  Calcium (CAS RN 7440-70-2) ; Calcium carbonate (CAS RN 471-34-1) ; Iron (CAS RN 7439-89-6)
• Federal Fiscal Year:
  2013
• Performing Organization:
  New York University School of Medicine - New York
• Peer Reviewed:
  True
• Start Date:
  20090915
• Source Full Name:
  American Journal of Industrial Medicine
• End Date:
  20120914
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b809928433cf7fca24fce02fae00c7f9a012f65a2a75ae3100adfc396a6a55434a0fbc62e0bfddd24fedd7363b02499f43b9df45c55b19fe6e5017e30ecbe0e5
• Download URL:
  https://stacks.cdc.gov/view/cdc/195036/cdc_195036_DS1.pdf
• File Type:
  [PDF - 1.07 MB ]