Nitrosothiol signaling in anoikis resistance and cancer metastasis

Details

• Personal Author:
  Azad N ; Iyer AKV ; Luanpitpong S ; Rojanasakul Y ; Wang L ; Azad N ; Iyer AKV ; Luanpitpong S ; Rojanasakul Y ; Wang L
• Description:
  Nitric oxide (NO) has been widely recognized as an important cell-signaling molecule that regulates various physiological and pathological processes. S-nitrosylation, or covalent attachment of NO to protein sulfhydryl groups, is a key mechanism by which NO regulates protein functions and cellular processes. In this article we discuss the various roles of NO and protein nitrosylation in cancer development, with a focus on cell invasion and anoikis resistance, both of which are key determinants of cancer metastasis. We specially address some of the mechanisms by which NO-mediated S-nitrosylation modulates substrates that have putative effects on key steps of metastasis. We propose that nitrosothiol signaling is a key regulatory mechanism common to several pathways involved in cancer progression and metastasis, and identifying such a mechanism will improve our understanding of the disease process and aid in the development of novel anticancer therapeutics. [Description provided by NIOSH]
• Subjects:
  Neoplasms Occupational Health Pathology Safety
• Keywords:
  Anoikis Author Keywords: Nitric Oxide Biological-effects Cancer Cell-damage Cell-morphology Cellular-function Cellular-reactions Disease-prevention Invasion Metastasis Molecular-biology Nitroso-compounds Oxides Physiological-response Proteins S-nitrosylation Sulfhydryls

  More +
• ISSN:
  2151-8017
• Document Type:
  Text
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  OSHA Region 3 ; Virginia ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  141-154
• Volume:
  3
• Issue:
  2
• NIOSHTIC Number:
  nn:20042964
• Citation:
  For Immunopathol Dis Therap 2012 Apr-Jun; 3(2):141-154
• Contact Point Address:
  Yon Rojanasakul, PhD, West Virginia University, Health Sciences Center, P.O. Box 9530, Morgantown, WV 26506
• Email:
  yrojan@hsc.wvu.edu
• CAS Registry Number:
  Nitric oxide (CAS RN 10102-43-9) ; Nitric oxide (CAS RN 10102-43-9)
• Federal Fiscal Year:
  2012
• Peer Reviewed:
  True
• Source Full Name:
  Forum on Immunopathological Diseases and Therapeutics
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7e4721e0bd919cbb20e4a8fa477c0562002bd16c47b2c63088919beb8189ac2b9a57f38182af25e2b858f7de71258808105453da4aed0323de578d2a1cf52e01
• Download URL:
  https://stacks.cdc.gov/view/cdc/195011/cdc_195011_DS1.pdf
• File Type:
  [PDF - 2.52 MB ]