Potential for immune sensitization following dermal exposure to indium tin oxide

Details

• Personal Author:
  Anderson S ; Anderson, Kern E. ; Brock K ; Long CM ; Lukomska E ; Meade BJ
• Description:
  Pulmonary disease including pulmonary fibrosis, emphysema and pulmonary alveolar proteinosis has been observed in workers in the indium industry. The mechanisms underlying this disease and its natural history have not been fully elucidated. Among other findings, following inhalation exposure to Indium-tin Oxide (ITO) animal studies have revealed hyperplasia of mediastinal lymph nodes and granulomas of mediastinal nodes and bronchus-associated lymphoid tissue. These studies were undertaken to investigate the potential for ITO to induce immune sensitization using the mouse Local Lymph Node Assay. Furthermore studies were conducted following exposure to both intact and abraded skin to begin to evaluate the potential for dermal penetration of the nanoparticles. BALB/c mice (5 animals/per group for both intact and abraded skin groups) were exposed to either vehicle (dimethyl sulfoxide), increasing concentrations 2.5%-10% ITO (90:10 indium oxide/tin oxide, particle size <50 nm) or positive control (30% alpha-hexylcinnamaldehyde). A dose response was observed in both groups reaching statistical significance and a SI of 4 in the 5% intact dose group (EC3 value of 2.6). Students t-test showed no statistical differences when responses were compared between intact and breach skin exposures at the same dose levels. These studies demonstrate the potential for ITO to induce sensitization following dermal exposure and suggest that the particles may have similar bioavailability through intact and abraded skin. [Description provided by NIOSH]
• Subjects:
  Biological Assay Environmental Monitoring Hypersensitivity Immune System Laboratories Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety Skin Toxicology

  More +
• Keywords:
  Bioassays Dose-response Exposure-assessment Exposure-levels Immune-reaction Laboratory-animals Laboratory-techniques Lung-disorders Lung-function Lung-irritants Nanotechnology Oxides Pulmonary-function Pulmonary-system-disorders Respiratory-system-disorders Sensitization Skin-exposure Tin-oxides Tissue-culture

  More +
• ISSN:
  1096-6080
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 3 ; OSHA Region 6 ; Texas ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  90
• Volume:
  132
• Issue:
  1
• NIOSHTIC Number:
  nn:20042389
• Citation:
  Toxicologist 2013 Mar; 132(1):90
• CAS Registry Number:
  3-8-Angiotensin II (CAS RN 12676-15-2) ; Indium (CAS RN 7440-74-6) ; Indium tin oxide (In1.69Sn0.15O2.85) (CAS RN 71243-84-0) ; Tin oxide (SnO2) (CAS RN 18282-10-5) ; α-Hexylcinnamaldehyde (CAS RN 101-86-0)
• Federal Fiscal Year:
  2013
• Peer Reviewed:
  False
• Source Full Name:
  The Toxicologist. Society of Toxicology 52nd Annual Meeting and ToxExpo, March 10-14, 2013, San Antonio, Texas
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0a562790077d092eb1424aaa813f5546e5ee52ea923ffee6baf5dabab30dc84df628df5a99335d036c952acdfba12376d34d56674122504d1bb28cb25c24a24a
• Download URL:
  https://stacks.cdc.gov/view/cdc/194621/cdc_194621_DS1.pdf
• File Type:
  [PDF - 2.13 MB ]