NIOH and NIOSH Basis for an Occupational Health Standard: Di(2-ethylhexyl)phthalate (DEHP)

Details

• Journal Article:
  National Institute for Occupational Safety and Health
• Personal Author:
  Garberg, Per ; Hogberg, Johan ; Lundberg, Ingvar ; Lundberg, Per
• Description:
  Health effects of exposure to di(2-ethylhexyl)phthalate (117817) (DEHP) were reviewed. Topics included: physical and chemical properties; occupational exposure to DEHP; kinetics and metabolism; acute toxicity; biochemical effects; skin and eye irritation; chronic toxicity; reproductive, embryotoxic and teratogenic effects; mutagenicity and genotoxicity; carcinogenicity; and effects on man. Time weighted average exposures in a phthalate manufacturing facility were 0.02 to 4.1mg/m3 for six heavily exposed workers. No accumulation has been observed. DEHP was found to have low acute toxicity. Long term exposures to rats has caused testicular atrophy. DEHP was carcinogenic and teratogenic in tests in rodents. Most genotoxicity tests have been negative. However, certain tests have indicated that DEHP may affect the genome in-vitro. [Description provided by NIOSH]
• Subjects:
  Carcinogens Hazardous Substances Laboratories Occupational Exposure Occupational Health Phthalic Acids Plastics Safety Teratogenesis Urogenital Diseases Urogenital System

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• Keywords:
  Phthalates; Plastics-industry; Laboratory-animals; Reproductive-hazards; Toxic-effects; Carcinogens; Teratogens; Genotoxic-effects
• Source:
  Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 90-110, 1990 Jan; :1-53
• Series:
  NIOSH Numbered Publications
• Subseries:
  Criteria Document
• DOI:
  https://doi.org/10.26616/NIOSHPUB90110
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Standards
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSDTT - Division of Standards Development and Technology Transfer
• Topic:
  Workplace Safety & Health
• Location:
  North America ; Europe
• Pages in Document:
  53 pdf pages
• NIOSHTIC Number:
  nn:00196013
• NTIS Accession Number:
  PB91-140871
• CAS Registry Number:
  Dioctyl phthalate (CAS RN 117-81-7)
• Federal Fiscal Year:
  1990
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health Guidelines and Recommendations
• Main Document Checksum:
  urn:sha-512:34b9f7a180a2e6ca04d5a6297929d1beee4dcf01b265004706b8f183b9efdf2ea5388baf428e63dc031d881adc2d25834c9de6d1a60e3d4041be88763bc1c526
• Download URL:
  https://stacks.cdc.gov/view/cdc/19456/cdc_19456_DS1.pdf
• File Type:
  [PDF - 990.88 KB ]