Polymorphisms in glutathione S-transferases in French vinyl chloride workers

Details

• Personal Author:
  Brandt-Rauf PW ; Lee, Stephen A. ; Li Y ; Marion M-J ; Zhou M
• Description:
  The authors have recently demonstrated a significant gene-environment interaction between vinyl chloride exposure and polymorphisms in the DNA repair protein XRCC1 on the occurrence of mutant p53 biomarkers of vinyl chloride-induced genetic damage. The aim of this study was to examine the polymorphisms in the glutathione S-transferases (GSTs) as potential modifiers of this relationship, since these enzymes may be involved in the phase II metabolism of the reactive intermediates of vinyl chloride. A cohort of 211 French vinyl chloride workers was genotyped for common polymorphisms in GSTM1, GSTT1 and GSTP1. Although no independent, statistically significant effect of these polymorphisms on the occurrence of the mutant p53 biomarker was found, the null GSTM1 and null GSTT1 polymorphisms were found to interact with the XRCC1 polymorphism to increase the occurrence of the biomarker such that, for example, workers with at least one variant XRCC1 allele who were null for both GSTM1 and GSTT1 had a significant odds ratio for the biomarker (OR=8.4, 95% CI=1.3-54.0) compared with workers who were wild-type for all alleles, controlling for potential confounders including cumulative vinyl chloride exposure. [Description provided by NIOSH]
• Subjects:
  Biomarkers Energy Metabolism Environmental Health Enzymes Genetics Men Occupational Health Safety Women
• Keywords:
  Author Keywords: Metabolism DNA Repair Environmental-factors Exposure-levels Gene-environment Interaction Genes Humans Mutations P53 Proteins Workers

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• ISSN:
  1354-750X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  72-79
• Volume:
  10
• Issue:
  1
• NIOSHTIC Number:
  nn:20042188
• Citation:
  Biomarkers 2005 Jan-Feb; 10(1):72-79
• Contact Point Address:
  Paul W. Brandt-Rauf, Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, 60 Haven Avenue, B-1, New York, NY 10032
• Email:
  pwb1@columbia.edu
• CAS Registry Number:
  Glutathione (CAS RN 70-18-8) ; Vinyl chloride (CAS RN 75-01-4)
• Federal Fiscal Year:
  2005
• NORA Priority Area:
  Work Environment and Workforce: Special Populations
• Performing Organization:
  Department of Environmental Health Sciences, The Mailman School of Public Health, Columbia University, New York, New York
• Peer Reviewed:
  True
• Start Date:
  20010701
• Source Full Name:
  Biomarkers
• End Date:
  20150831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3ad03cb14404c5d2b7e02c5f1727507168801318deb8a597f65eea755f2d1a41f02cb52dda5e3afafa02fe8c8f00bc8a83d936df939b0e30f8bd32f3eebc27a0
• Download URL:
  https://stacks.cdc.gov/view/cdc/194490/cdc_194490_DS1.pdf
• File Type:
  [PDF - 109.82 KB ]