Inflammatory biomarkers predict airflow obstruction after exposure to World Trade Center dust

Details

• Personal Author:
  Aldrich TK ; Cohen HW ; Comfort AL ; Ferrier N ; Glaser MS ; Hall CB ; Kasturiarachchi KJ ; Kelly K ; Kwon S ; Naveed B ; Nolan A ; Prezant DJ ; Rom, William N. ; Webber MP ; Weiden MD ; Zeig-Owens R
• Description:
  BACKGROUND: The World Trade Center (WTC) collapse on September 11, 2001, produced airflow obstruction in a majority of firefighters receiving subspecialty pulmonary evaluation (SPE) within 6.5 years post-September 11, 2001. METHODS: In a cohort of 801 never smokers with normal pre-September 11, 2001, FEV1, we correlated inflammatory biomarkers and CBC counts at monitoring entry within 6 months of September 11, 2001, with a median FEV(1) at SPE (34 months; interquartile range, 25-57). Cases of airflow obstruction had FEV(1) less than the lower limit of normal (LLN) (100 of 801; 70 of 100 had serum), whereas control subjects had FEV(1) greater than or equal to LLN (153 of 801; 124 of 153 had serum). RESULTS: From monitoring entry to SPE years later, FEV(1) declined 12% in cases and increased 3% in control subjects. Case subjects had elevated serum macrophage derived chemokine (MDC), granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulating factor, and interferon inducible protein-10 levels. Elevated GM-CSF and MDC increased the risk for subsequent FEV(1) less than LLN by 2.5-fold (95% CI, 1.2-5.3) and 3.0-fold (95% CI, 1.4-6.1) in a logistic model adjusted for exposure, BMI, age on September 11, 2001, and polymorphonuclear neutrophils. The model had sensitivity of 38% (95% CI, 27-51) and specificity of 88% (95% CI, 80-93). CONCLUSIONS: Inflammatory biomarkers can be risk factors for airflow obstruction following dust and smoke exposure. Elevated serum GM-CSF and MDC levels soon after WTC exposure were associated with increased risk of airflow obstruction in subsequent years. Biomarkers of inflammation may help identify pathways producing obstruction after irritant exposure. [Description provided by NIOSH]
• Subjects:
  Aging Biomarkers Blood Dust Firefighters Hematologic Tests Irritants Lung Men Occupational Health Respiratory System Respiratory Tract Diseases Safety Women

  More +
• Keywords:
  Age-groups Airway-obstruction Blood-analysis Blood-cells Blood-tests Dust-exposure Dust-inhalation Dusts Etiology Fire-fighters Humans Monitors Pulmonary-function Pulmonary-system Pulmonary-system-disorders Respiration Respiratory-irritants Respiratory-system-disorders Time-weighted-average-exposure

  More +
• ISSN:
  0012-3692
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  412-418
• Volume:
  142
• Issue:
  2
• NIOSHTIC Number:
  nn:20041934
• Citation:
  Chest 2012 Aug; 142(2):412-418
• Contact Point Address:
  Michael D. Weiden, MD, NYU School of Medicine, 550 1st Ave, New York, NY 10016
• Email:
  michael.weiden@med.nyu.edu
• Federal Fiscal Year:
  2012
• Performing Organization:
  New York City Fire Department
• Peer Reviewed:
  True
• Start Date:
  20040701
• Source Full Name:
  Chest
• End Date:
  20110630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:775beeeb59d1ee5d9ffbf18c046934b8adfde03481b8cc73dd95ed44ed39e5d059c450e27ea31108b149d696eceb2a7207289df1c510d02ec595cea8598bb719
• Download URL:
  https://stacks.cdc.gov/view/cdc/194341/cdc_194341_DS1.pdf
• File Type:
  [PDF - 782.06 KB ]