New perspectives for in vitro risk assessment of multiwalled carbon nanotubes: application of coculture and bioinformatics

Details

• Personal Author:
  Castranova, Vincent ; Guo NL ; Qian Y ; Snyder-Talkington BN
• Description:
  Nanotechnology is a rapidly expanding field with wide application for industrial and medical use; therefore, understanding the toxicity of engineered nanomaterials is critical for their commercialization. While short-term in vivo studies have been performed to understand the toxicity profile of various nanomaterials, there is a current effort to shift toxicological testing from in vivo observational models to predictive and high-throughput in vitro models. However, conventional monoculture results of nanoparticle exposure are often disparate and not predictive of in vivo toxic effects. A coculture system of multiple cell types allows for cross-talk between cells and better mimics the in vivo environment. This review proposes that advanced coculture models, combined with integrated analysis of genome-wide in vivo and in vitro toxicogenomic data, may lead to development of predictive multigene expression-based models to better determine toxicity profiles of nanomaterials and consequent potential human health risk due to exposure to these compounds. [Description provided by NIOSH]
• Subjects:
  Cells, Cultured Hazardous Substances Manufacturing And Industrial Facilities Occupational Health Risk Assessment Risk Factors Safety
• Keywords:
  Analytical-processes Cell-cultures Exposure-levels In-vitro-study In-vivo-studies Industrial-environment Models Nanotechnology Risk-factors Toxic-effects Toxic-materials

  More +
• ISSN:
  1093-7404
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  468-492
• Volume:
  15
• Issue:
  7
• NIOSHTIC Number:
  nn:20041826
• Citation:
  J Toxicol Environ Health B 2012 Nov; 15(7):468-492
• Contact Point Address:
  Yong Qian, Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505-2888
• Email:
  yaq2@cdc.gov
• Federal Fiscal Year:
  2013
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Toxicology and Environmental Health, Part B: Critical Reviews
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9a6510ea5ee6c7cd17e74f5bd43a7bff977fa23ac6d0333f80e678fc3bc79540546f80e49ffdb18ded31e2d699eac64da04ee851285c14d3742ebdb536e0b5ef
• Download URL:
  https://stacks.cdc.gov/view/cdc/194279/cdc_194279_DS1.pdf
• File Type:
  [PDF - 293.90 KB ]