Exposure to triclosan augments the allergic response to ovalbumin in a mouse model of asthma

Details

• Personal Author:
  Anderson KL ; Anderson, Stacey E. ; Franko J ; Hubbs, Ann F. ; Kashon ML ; Lukomska E ; Meade BJ
• Description:
  During the last decade there has been a remarkable and unexplained increase in the prevalence of asthma. These studies were conducted to investigate the role of dermal exposure to triclosan, an endocrine-disrupting compound, on the hypersensitivity response to ovalbumin (OVA) in a murine model of asthma. Triclosan has had widespread use in the general population as an antibacterial and antifungal agent and is commonly found in consumer products such as soaps, deodorants, toothpastes, shaving creams, mouth washes, and cleaning supplies. For these studies, BALB/c mice were exposed dermally to concentrations of triclosan ranging from 0.75-3% (0.375-1.5 mg/mouse/day) for 28 consecutive days. Concordantly, mice were intraperitoneally injected with OVA (0.9 microg) and aluminum hydroxide (0.5 mg) on days 1 and 10 and challenged with OVA (125 microg) by pharyngeal aspiration on days 19 and 27. Compared to the animals exposed to OVA alone, increased spleen weights, OVA-specific IgE, Interleukin (IL)-13 cytokine levels, and numbers of lung eosinophils were demonstrated when mice were co-exposed to OVA and triclosan. Statistically significant increases in OVA-specific and non-specific airway hyperreactivity (AHR) were observed for all triclosan co-exposed groups when compared to the vehicle and OVA controls. In these studies exposure to triclosan alone was not demonstrated to be allergenic, however; co-exposure with a known allergen resulted in enhancement of the hypersensitivity response to that allergen, suggesting that triclosan exposure may augment the allergic responses to other environmental allergens. [Description provided by NIOSH]
• Subjects:
  Aluminum Compounds Animals Asthma Asthma, Occupational Cytotoxins Endocrine System Environmental Monitoring Hypersensitivity Laboratories Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety Skin Toxicology

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• Keywords:
  Airway-resistance Allergens Allergic-reactions Aluminum-compounds Analytical-models Animal-studies Antibacterial-agents Antifungals Asthma Author Keywords: Triclosan Bronchial-asthma Chemical Adjuvancy Cytotoxic-effects Dose-response Endocrine-function Endocrine-system Exposure-assessment Exposure-levels Laboratory-animals Laboratory-techniques Laboratory-testing Lung-cells Lung-disorders Lung-function Lung-irritants Pulmonary-function Pulmonary-system-disorders Respiratory-system-disorders Skin-exposure

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• ISSN:
  1096-6080
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  96-106
• Volume:
  132
• Issue:
  1
• NIOSHTIC Number:
  nn:20041820
• Citation:
  Toxicol Sci 2013 Mar; 132(1):96-106
• Contact Point Address:
  Stacey E. Anderson, Ph.D, National Institute for Occupational Safety and Health (NIOSH), 1095 Willowdale Drive, Morgantown, WV 26505
• Email:
  Sanderson4@cdc.gov
• CAS Registry Number:
  Aluminum hydroxide (CAS RN 21645-51-2) ; Triclosan (CAS RN 3380-34-5)
• Federal Fiscal Year:
  2013
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Toxicological Sciences
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7a5b0c2ce08ee8d8dbef3fc44f232589f7a6f51becf63edb5709de70967cdf372754759073bd8d5b18fb5c5472fe13c8fec84463dbb17752f30f8b9f19e64cbb
• Download URL:
  https://stacks.cdc.gov/view/cdc/194273/cdc_194273_DS1.pdf
• File Type:
  [PDF - 29.73 MB ]