Genome-wide association study of glioma and meta-analysis

Ahlbom A; Albanes D; Andersson U; Beane Freeman LE; Bondy M; Braganza M; Buring JE; Butler MA; Carreon T; Chanock SJ; Chatterjee N; Decker P; Enciso-Mora V; Feychting M; Fleming SJ; Fraumeni JF Jr.; Fridley B; Gao Y-T; Gapstur SM; Gaziano JM; Giles GG; Hallmans G; Hartge P; Henriksson R; Hoffman-Bolton J; Hoover RN; Houlston R; Inskip PD; Jenkins RB; Johansen C; Kitahara CM; Kosel M; Lachance DH; Lathrop M; Lau C; Linet MS; Liu C; Lonn S; Marchand LL; McKean-Cowdin R; Melin BS; Michaud DS; Peters U; Purdue MP; Rajaraman P; Rice T; Rothman N; Ruder, Avima M.; Sanson M; Sesso HD; Severi G; Shete S; Shu X-O; Simon M; Stampfer M; Stevens VL; Swerdlow A; Visvanathan K; Wang SS; Wang Z; White E; Wiemels JL; Wiencke JK; Wolk A; Wrensch M; Xiang Y-B; Xiao Y; Yeager M; Zeleniuch-Jacquotte A; Zheng W

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Genome-wide association study of glioma and meta-analysis

Public Domain

2012/12/01
By Ahlbom A ; Albanes D ; Andersson U ; ...

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Personal Author:

Ahlbom A ; Albanes D ; Andersson U ; Beane Freeman LE ; Bondy M ; Braganza M ; Buring JE ; Butler MA ; Carreon T ; Chanock SJ ; Chatterjee N ; Decker P ; Enciso-Mora V ; Feychting M ; Fleming SJ ; Fraumeni JF Jr. ; Fridley B ; Gao Y-T ; Gapstur SM ; Gaziano JM ; Giles GG ; Hallmans G ; Hartge P ; Henriksson R ; Hoffman-Bolton J ; Hoover RN ; Houlston R ; Inskip PD ; Jenkins RB ; Johansen C ; Kitahara CM ; Kosel M ; Lachance DH ; Lathrop M ; Lau C ; Linet MS ; Liu C ; Lonn S ; Marchand LL ; McKean-Cowdin R ; Melin BS ; Michaud DS ; Peters U ; Purdue MP ; Rajaraman P ; Rice T ; Rothman N ; Ruder, Avima M. ; Sanson M ; Sesso HD ; Severi G ; Shete S ; Shu X-O ; Simon M ; Stampfer M ; Stevens VL ; Swerdlow A ; Visvanathan K ; Wang SS ; Wang Z ; White E ; Wiemels JL ; Wiencke JK ; Wolk A ; Wrensch M ; Xiang Y-B ; Xiao Y ; Yeager M ; Zeleniuch-Jacquotte A ; Zheng W
Description:

Gliomas account for approximately 80 % of all primary malignant brain tumors and, despite improvements in clinical care over the last 20 years, remain among the most lethal tumors, underscoring the need for gaining new insights that could translate into clinical advances. Recent genome-wide association studies (GWAS) have identified seven new susceptibility regions. We conducted a new independent GWAS of glioma using 1,856 cases and 4,955 controls (from 14 cohort studies, 3 case-control studies, and 1 population-based case-only study) and found evidence of strong replication for three of the seven previously reported associations at 20q13.33 (RTEL), 5p15.33 (TERT), and 9p21.3 (CDKN2BAS), and consistent association signals for the remaining four at 7p11.2 (EGFR both loci), 8q24.21 (CCDC26) and 11q23.3 (PHLDB1). The direction and magnitude of the signal were consistent for samples from cohort and case-control studies, but the strength of the association was more pronounced for loci rs6010620 (20q,13.33; RTEL) and rs2736100 (5p15.33, TERT) in cohort studies despite the smaller number of cases in this group, likely due to relatively more higher grade tumors being captured in the cohort studies. We further examined the 85 most promising single nucleotide polymorphism (SNP) markers identified in our study in three replication sets (5,015 cases and 11,601 controls), but no new markers reached genome-wide significance. Our findings suggest that larger studies focusing on novel approaches as well as specific tumor subtypes or subgroups will be required to identify additional common susceptibility loci for glioma risk. [Description provided by NIOSH]
Subjects:

Biomarkers Genetics Neoplasms Nervous System Nervous System Diseases Nucleotides Occupational Health Risk Assessment Risk Factors Safety
Keywords:

Biological-effects Brain-tumors Cancer Gene-mutation Genes Genetic-factors Malignancy Malignant-neoplasms Risk-analysis Risk-factors Tumors
ISSN:

0340-6717
Document Type:

Text
Genre:

Journal Article
Place as Subject:

California ; Georgia ; Hawaii ; Maryland ; Massachusetts ; Minnesota ; New York ; Ohio ; OSHA Region 1 ; OSHA Region 10 ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 6 ; OSHA Region 9 ; Rhode Island ; Tennessee ; Texas ; Washington
CIO:

National Institute for Occupational Safety and Health (NIOSH)
Division:

DART - Division of Applied Research and Technology ; DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
Topic:

Workplace Safety & Health
Location:

North America
Volume:

131
Issue:

12
NIOSHTIC Number:

nn:20041783
Citation:

Hum Genet 2012 Dec; 131(12):1877-1888
Contact Point Address:

P. Rajaraman, Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, Bethesda, MD, USA
Email:

rajarama@mail.nih.gov
Federal Fiscal Year:

2013
NORA Priority Area:

Manufacturing
Peer Reviewed:

True
Source Full Name:

Human Genetics
Collection(s):

National Institute for Occupational Safety and Health
Main Document Checksum:

urn:sha-512:917cfbb8abe7ffa79bf0a98b8a1251e88084eb6b37c5b18a9aeaa0666c440f0b281704c458b8b1432b17b59691d3d674f224e00b1a57a8bf1b106220b3074d3f
Download URL:

https://stacks.cdc.gov/view/cdc/194249/cdc_194249_DS1.pdf
File Type:

[PDF - 299.40 KB ]

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