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Criteria for a Recommended Standard: Occupational Exposure to o-Tolidine
  • Published Date:
    August 1978
  • Status:
Filetype[PDF - 1.83 MB]

  • Corporate Authors:
    National Institute for Occupational Safety and Health
  • Document Type:
  • Description:
    This report presents the criteria and the recommended standard to meet the need for preventing diseases injury arising from occupational exposure to o-tolidine. Absorption of o-tolidine through the intact skin and from the respiratory and gastrointestinal tracts has been reported. Cancer and kidney damage have been reported in animals exposed to o-tolidine alone at high doses. Bacterial tests of mutagenicity and mammalian tests of DNA damage further support the findings of mammalian carcinogenicity. Furthermore, o-tolidine resembles benzidine, a known human carcinogen, in chemical structure, physical properties, and metabolism and excretion. o-tolidine is, therefore, judged to pose a risk of cancer in workers. The recommended standard for occupational exposure to o-tolidine is based on keeping exposure at the lowest possible level through engineering controls and work practices. The recommended sampling and analytical methods have been evaluated for benzidine and are expected to be useful for o-tolidine.

  • Supporting Files:
    No Additional Files