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Criteria for a Recommended Standard: Occupational Exposure to Ketones
  • Published Date:
    June 1978
  • Status:
    current
Filetype[PDF - 3.64 MB]


Details:
  • Corporate Authors:
    National Institute for Occupational Safety and Health
  • Document Type:
  • Description:
    This report presents the criteria and the recommended standard based thereon that were prepared to meet the need for preventing impairment of health from workplace exposure to ketones. There are a number of areas that need further research with respect to ketones. The possibilities of carcinogenic, mutagenic, teratogenic, and reproductive effects from ketones have not been thoroughly investigated. Epidemiologic studies on all of the ketones are also needed,. Furthermore, toxicologic information from repeated exposures of experimental animals is deficient for most of the ketones. Animal experiments are needed to determine if ketones other than methyl n-butyl ketone produce peripheral neuropathy. The effects of various mixtures of the ketones and interactions that may occur have not been studied. Research in this complex area is needed. Pharmacokinetic studies (absorption, distribution, metabolism, and excretion) are also needed to help investigators understand the mechanism of action of ketones on the nervous system.

    Exposure to ketones in the workplace is a major concern because one of these compounds has caused a neurologic disorder, and all of them may cause irritation of the eyes, nose, and throat, impaired judgment, and narcosis in humans. Exposure occurs primarily when ketones are inhaled or absorbed through the skin.This report presents the criteria and the recommended standard based thereon that were prepared to meet the need for preventing impairment of health from workplace exposure to ketones. There are a number of areas that need further research with respect to ketones. The possibilities of carcinogenic, mutagenic, teratogenic, and reproductive effects from ketones have not been thoroughly investigated. Epidemiologic studies on all of the ketones are also needed,. Furthermore, toxicologic information from repeated exposures of experimental animals is deficient for most of the ketones. Animal experiments are needed to determine if ketones other than methyl n-butyl ketone produce peripheral neuropathy. The effects of various mixtures of the ketones and interactions that may occur have not been studied. Research in this complex area is needed. Pharmacokinetic studies (absorption, distribution, metabolism, and excretion) are also needed to help investigators understand the mechanism of action of ketones on the nervous system.

    Exposure to ketones in the workplace is a major concern because one of these compounds has caused a neurologic disorder, and all of them may cause irritation of the eyes, nose, and throat, impaired judgment, and narcosis in humans. Exposure occurs primarily when ketones are inhaled or absorbed through the skin.This report presents the criteria and the recommended standard based thereon that were prepared to meet the need for preventing impairment of health from workplace exposure to ketones. There are a number of areas that need further research with respect to ketones. The possibilities of carcinogenic, mutagenic, teratogenic, and reproductive effects from ketones have not been thoroughly investigated. Epidemiologic studies on all of the ketones are also needed,. Furthermore, toxicologic information from repeated exposures of experimental animals is deficient for most of the ketones. Animal experiments are needed to determine if ketones other than methyl n-butyl ketone produce peripheral neuropathy. The effects of various mixtures of the ketones and interactions that may occur have not been studied. Research in this complex area is needed. Pharmacokinetic studies (absorption, distribution, metabolism, and excretion) are also needed to help investigators understand the mechanism of action of ketones on the nervous system.

    Exposure to ketones in the workplace is a major concern because one of these compounds has caused a neurologic disorder, and all of them may cause irritation of the eyes, nose, and throat, impaired judgment, and narcosis in humans. Exposure occurs primarily when ketones are inhaled or absorbed through the skin.This report presents the criteria and the recommended standard based thereon that were prepared to meet the need for preventing impairment of health from workplace exposure to ketones. There are a number of areas that need further research with respect to ketones. The possibilities of carcinogenic, mutagenic, teratogenic, and reproductive effects from ketones have not been thoroughly investigated. Epidemiologic studies on all of the ketones are also needed,. Furthermore, toxicologic information from repeated exposures of experimental animals is deficient for most of the ketones. Animal experiments are needed to determine if ketones other than methyl n-butyl ketone produce peripheral neuropathy. The effects of various mixtures of the ketones and interactions that may occur have not been studied. Research in this complex area is needed. Pharmacokinetic studies (absorption, distribution, metabolism, and excretion) are also needed to help investigators understand the mechanism of action of ketones on the nervous system.

    Exposure to ketones in the workplace is a major concern because one of these compounds has caused a neurologic disorder, and all of them may cause irritation of the eyes, nose, and throat, impaired judgment, and narcosis in humans. Exposure occurs primarily when ketones are inhaled or absorbed through the skin.

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