Brain organochlorines and Lewy pathology: the Honolulu-Asia aging study

Details

• Personal Author:
  Abbott RD ; Duda JE ; Launer L ; Masaki K ; Miller DB ; Noorigian JV ; O'Callaghan JP ; Pellizzari E ; Petrovitch H ; Ross GW ; Tanner CM ; White LR
• Description:
  Although organochlorines have been reported more frequently in Parkinson's disease (PD) brains than in controls, the association with brain Lewy pathology is unknown. Honolulu-Asia Aging Study (HAAS) participants, exposed to organochlorines from a variety of sources during midlife, represent a population well suited to determining the relationship of brain organochlorines with Lewy pathology in decedents from the longitudinal HAAS. The study design included the measurement of 21 organochlorine levels in frozen occipital lobe samples from HAAS decedents. Alpha-synuclein immunostaining performed on 225 brains was used to identify Lewy bodies and Lewy neurites. With the potential for spurious associations to appear between Lewy pathology and 17 organochlorine compounds found in at least 1 brain, initial assessments identified heptachlor epoxide isomer b, methoxychlor, and benzene hexachloride b as being most important. The prevalence of Lewy pathology was 75% (6 of 8) among brains with any 2 of the 3 compounds, 48.8% (79 of 162) among those with 1, and 32.7% (18 of 55) for those with neither (P = .007 test for trend). Although findings persisted after removing cases with PD and dementia with Lewy bodies and after adjustment for age at death, body mass index, pack-years of cigarette smoking, and coffee intake (P = .013), the results were insignificant when correcting for multiple testing. Although consistent with earlier accounts of an association between organochlorines and clinical PD, associations with Lewy pathology warrant further study. [Description provided by NIOSH]
• Subjects:
  Age Factors Benzene Chlorine Compounds Epoxy Compounds Insecticides Nervous System Nervous System Diseases Occupational Health Pathology Safety
• Keywords:
  Age-factors Author Keywords: Parkinsons Disease Benzenes Brain-disorders Brain-function Epoxides Lewy Body Long-term-study Neurological-reactions Neurological-system Organo-chlorine-compounds Organochlorines Pesticides

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• ISSN:
  1531-8257
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  California ; Hawaii ; Maryland ; North Carolina ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 9 ; Pennsylvania ; Virginia ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  27
• Issue:
  11
• NIOSHTIC Number:
  nn:20041638
• Citation:
  Mov Disord 2012 Sep; 27(11):1418-1424
• Contact Point Address:
  Dr. G. Webster Ross, MD, VA Pacific Islands Health Care System, 459 Patterson Road, Honolulu, HI 96819, USA
• Email:
  george.ross@va.gov
• CAS Registry Number:
  Heptachlor (CAS RN 76-44-8) ; Methoxychlor (CAS RN 72-43-5) ; β-Hexachlorocyclohexane (CAS RN 319-85-7)
• Federal Fiscal Year:
  2012
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Peer Reviewed:
  True
• Source Full Name:
  Movement Disorders
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1ba1040158739ab025da9323575f215d5a76bd80d94651d4c4148d2aac4cc0e333ac3b3367079ff868922f4cabc7183640b0cf49b38418f6ca176087d613cdf5
• Download URL:
  https://stacks.cdc.gov/view/cdc/194140/cdc_194140_DS1.pdf
• File Type:
  [PDF - 252.25 KB ]