Risk of cervical cancer among female autoworkers exposed to metalworking fluids

Details

• Personal Author:
  Betenia N ; Costello S ; Eisen EA
• Description:
  OBJECTIVES: Cervical cancer is caused by human papilloma virus (HPV). However, only a small proportion of women infected with HPV, progress to cervical cancer. Other co-factors must therefore be necessary to cause cervical cancer. We examined cervical cancer in relation to occupational exposure to metalworking fluids (MWF), which are complex mixtures containing several known carcinogens. METHODS: A cohort of 4374 female autoworkers was followed from 1985-2004 for cancer diagnosis. Based on standardized incidence rates (SIR), we focused on cervical cancer in an internal analysis. Pooled logistic regression was used to model the relationship between exposure to three different types of MWF, selected constituents, and incidence of cervical cancer. RESULTS: Based on 40 cases, SIR were statistically significantly elevated for both race specific subgroups: 3.30 and 2.43, respectively for Caucasian and black women. The standard mortality ratio (SMR) was also statistically significantly elevated for Caucasian women (3.44) based on seven observed deaths. There was no association with oil-based straight fluid. Relative risks for soluble and synthetic MWF and nitrosamines were modestly elevated but not statistically significant. CONCLUSIONS: Water-based MWF may play a role in the etiology of cervical cancer. Further studies in larger cohorts of women are needed to clearly establish this relationship. [Description provided by NIOSH]
• Subjects:
  Automobiles Carcinogens Metals Metal Workers Neoplasms Nitrosamines Occupational Exposure Occupational Health Race Factors Risk Assessment Risk Factors Safety Viral Diseases Women

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• Keywords:
  Author Keywords: Nitrosamine Automotive-industry Cancer Employee-exposure Etiology Metal-compounds Metalworking Metalworking-fluids Occupation Racial-factors Risk-analysis Risk-factors SIR Soluble Metalworking Fluid Standardized Incidence Ratio Statistical-analysis Straight Metalworking Fluid Synthetic Metalworking Fluid Synthetics Viral-infections

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• ISSN:
  0355-3140
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  78-83
• Volume:
  38
• Issue:
  1
• NIOSHTIC Number:
  nn:20041626
• Citation:
  Scand J Work Environ Health 2012 Jan; 38(1):78-83
• Contact Point Address:
  Ellen A. Eisen, ScD, Environmental Health Sciences, School of Public Health, University of California Berkeley, Berkeley, CA 94720-7360, USA
• Email:
  eeisen@berkeley.edu
• Federal Fiscal Year:
  2012
• Performing Organization:
  University of California, Berkeley
• Peer Reviewed:
  True
• Start Date:
  20070801
• Source Full Name:
  Scandinavian Journal of Work, Environment & Health
• End Date:
  20100731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4a9769dcdbd32284d34da83b88cb75333313e0c3f78eaaacffb0967be29e8c89f177bcb6fb7e3cdf9bb37045afef08d8af62bf06f0820376e2b9d47a530e76f8
• Download URL:
  https://stacks.cdc.gov/view/cdc/194133/cdc_194133_DS1.pdf
• File Type:
  [PDF - 198.16 KB ]