Nanoparticle aerosol generation methods from bulk powders for inhalation exposure studies

Details

• Personal Author:
  Elzey S ; Grassian VH ; O'Shaughnessy PT ; Schmoll LH ; Elzey S ; Grassian VH ; O'Shaughnessy PT ; Schmoll LH
• Description:
  Inhalation toxicity studies of nanoparticles require production of test aerosols with a number of acceptable characteristics. Five different generation methods for producing a nanoparticle aerosol from the bulk powder were evaluated with the goal of producing an acceptable aerosol that is homogenous, has a consistent concentration over time in which the magnitude may be intentionally varied, and has a size distribution that is both unimodal and has a small geometric mean diameter relative to the primary particle size of the nanoparticle bulk powder. Four types of bulk powders were evaluated including titanium dioxide, silicon dioxide, polymer-coated silver, and single walled carbon nanotubes. A nebulizer was the only tested method able to produce a consistent aerosol of sufficient magnitude. However, the resulting aerosol contains particles derived from the carrier water. Prior sonication of the nanoparticle suspension alone was found to be not useful for deagglomerating nanoparticles. [Description provided by NIOSH]
• Subjects:
  Aerosols Air Pollutants, Occupational Dust Environmental Monitoring Occupational Health Particulate Matter Safety
• Keywords:
  Aerosol Generators Air-samples Airborne-dusts Analytical-instruments Author Keywords: Nanoparticles Dust-measurement Measurement-equipment Nanotechnology Nebulizer Particle-aerodynamics Particle-counters Particulate-dust Respirable-dust Testing-equipment

  More +
• ISSN:
  1743-5390
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  Iowa ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  265-275
• Volume:
  3
• Issue:
  4
• NIOSHTIC Number:
  nn:20041467
• Citation:
  Nanotoxicology 2009 Dec; 3(4):265-275
• Contact Point Address:
  Patrick O'Shaughnessy, PhD, Department of Occupational and Environmental Health, The University of Iowa, 100 Oakdale Campus, 137 IREH, Iowa City, IA, 52242, USA
• Email:
  patrick-oshaughnessy@uiowa.edu
• Federal Fiscal Year:
  2010
• Performing Organization:
  University of Iowa
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Nanotoxicology
• End Date:
  20080630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ab79ec1de700d40b3f931d4cc3e3e398144c537996353c12b414fa778aab4d7da301bf39d386bb1b568eb193313fa229c43a27988e2355bc74e33f7e726f751b
• Download URL:
  https://stacks.cdc.gov/view/cdc/194034/cdc_194034_DS1.pdf
• File Type:
  [PDF - 1.39 MB ]