Characterization of a vortex shaking method for producing airborne glass fibers for toxicology studies

Details

• Personal Author:
  Deye G ; Ku BK ; Turkevich LA
• Description:
  Current fiber measurement techniques arose primarily due to health concerns over asbestos exposure. Fiber toxicity appears to be mostly a function of fiber concentration, dimensions (diameter and length) and durability in the lungs. A fiber length classifier (FLC) was used to identify the toxicity of fiber length for an in vitro study (Zeidler-Erdely et al., 2006), but an important technological barrier to toxicological testing is the inability to generate large quantities of fibers in narrow length-classified size ranges (NIOSH Asbestos Roadmap, 2011). To improve the performance of the FLC for toxicology studies, it is necessary to generate well-dispersed (or less agglomerated) airborne fibers at high concentrations to the inlet of the FLC. A vortex shaking method has been used to aerosolize fibrous particles such as carbon nanofibers and carbon nanotubes in previous studies because it is simple and easy to use (Ku et al., 2006; Maynard et al, 2007). In this study we investigate characteristics of a vortex-tube shaking method for different initial batch amounts of glass fibers. Also, the effect of pre-shaking and concentration decay with time are investigated. [Description provided by NIOSH]
• Subjects:
  Aerosols Air Pollutants, Occupational Asbestos Glass Hazardous Substances Inorganic Chemicals Lung Occupational Health Particulate Matter Respiratory System Safety Toxicology

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• Keywords:
  Aerodynamic Diameter Aerosol-generators Airborne-fibers Analytical-processes Asbestos-fibers Author Keywords: Glass Fiber Fibrous-bodies Fibrous-glass In-vitro-study Length Measurement-equipment Nanotechnology Testing-equipment Toxic-effects Toxic-materials Vortex Shaking

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• ISBN:
  9781466562769
• Publisher:
  CRC Press
• Document Type:
  Text
• Genre:
  Proceedings
• Place as Subject:
  California ; Ohio ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  358-360
• Volume:
  3
• NIOSHTIC Number:
  nn:20041464
• Citation:
  Nanotechnology 2012: Bio Sensors, Instruments, Medical, Environment and Energy: Technical Proceedings of the 2012 Nsti Nanotechnology Conference and Expo, June 18-21, 2012, Santa Clara, California, U.S.A. Romanowicz BF, Laudon M, eds., Boca Raton, FL: CRC Press, 2012 Jun; 3:358-360
• Email:
  BKu@cdc.gov
• Editor(s):
  Romanowicz BF; Laudon M
• Federal Fiscal Year:
  2012
• NORA Priority Area:
  Manufacturing ; Mining
• Peer Reviewed:
  False
• Source Full Name:
  Nanotechnology 2012: Bio Sensors, Instruments, Medical, Environment and Energy: Technical Proceedings of the 2012 Nsti Nanotechnology Conference and Expo, June 18-21, 2012, Santa Clara, California, U.S.A.
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ace8bfd58b2775935edd1ef678739a08e5f11ae666bb3d38f990d5c257ec591615dc827fa5312c1e50d4575159b811890bdf0cd3d78c7e072959b2cb02037e85
• Download URL:
  https://stacks.cdc.gov/view/cdc/194031/cdc_194031_DS1.pdf
• File Type:
  [PDF - 60.88 KB ]