Occupational exposure to chlorinated solvents and risks of glioma and meningioma in adults

Details

• Personal Author:
  Coble JB ; Hein, Misty J. ; Inskip PD ; Linet MS ; Neta G ; Purdue MP ; Rajaraman P ; Samanic C ; Stewart PA ; Waters MA
• Description:
  Objectives: Chlorinated solvents are classified as probable or possible carcinogens. It is unknown whether exposure to these agents increases the risk of malignant or benign brain tumours. Our objective was to evaluate associations of brain tumour risk with occupational exposure to six chlorinated solvents (ie, dichloromethane, chloroform, carbon tetrachloride, 1,1,1-trichloroethane, trichloroethylene and perchloroethylene). Methods: 489 glioma cases, 197 meningioma cases and 799 controls were enrolled in a hospital-based case-control study conducted at three USA hospitals in Arizona, Massachusetts and Pennsylvania. Information about occupational history was obtained through a detailed in-person interview that included job-specific modules of questions such that the interview was tailored to each individual's particular work history. An industrial hygienist assessed potential solvent exposure based on this information and an exhaustive review of the relevant industrial hygiene literature. Unconditional logistic regression models were used to calculate OR and 95% CI for each solvent forever/never, duration, cumulative, average weekly and highest exposure. Results: Overall, we found no consistent evidence of an increased risk of glioma or meningioma related to occupational exposure to the six chlorinated solvents evaluated. There was some suggestion of an association between carbon tetrachloride and glioma in analyses restricted to exposed subjects, with average weekly exposure above the median associated with increased risk compared with below the median exposure (OR= 7.1, 95% CI 1.1 to 45.2). Conclusions: We found no consistent evidence for increased brain tumour risk related to chlorinated solvents. [Description provided by NIOSH]
• Subjects:
  Carcinogens Chlorine Chlorine Compounds Environmental Monitoring Neoplasms Nervous System Nervous System Diseases Occupational Exposure Occupational Health Risk Assessment Safety Solvents Surveys And Questionnaires

  More +
• Keywords:
  Brain-tumors Chlorides Chlorinated-ethanes Chlorinated-ethylenes Chlorine-compounds Employee-exposure Exposure-assessment Industrial-hygiene Industrial-hygienists Malignant-neoplasms Mathematical-models Medical-surveys Risk-analysis Statistical-analysis Tumorigens

  More +
• ISSN:
  1351-0711
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; Ohio ; OSHA Region 3 ; OSHA Region 5 ; Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  69
• Issue:
  11
• NIOSHTIC Number:
  nn:20041268
• Citation:
  Occup Environ Med 2012 Nov; 69(11):793-801
• Contact Point Address:
  Dr Gila Neta, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, EPS, Room 7092, 6120 Executive Boulevard, Bethesda, MD 20852-7244, USA
• Email:
  netagil@mail.nih.gov
• CAS Registry Number:
  1,1,1-Trichloroethane (CAS RN 71-55-6) ; Carbon tetrachloride (CAS RN 56-23-5) ; Chloroform (CAS RN 67-66-3) ; Dichloromethane (CAS RN 75-09-2) ; Tetrachloroethylene (CAS RN 127-18-4) ; Trichloroethylene (CAS RN 79-01-6)
• Federal Fiscal Year:
  2013
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Occupational and Environmental Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:bd6f7e6cf652d09da985a22a4ad0852e72c5952770a5c41bdf299b114eaf31eeb44d73a52301c7c5d5e55f04cb8069ddcf08ac93451a07dc597cc7c9cb4591bd
• Download URL:
  https://stacks.cdc.gov/view/cdc/193873/cdc_193873_DS1.pdf
• File Type:
  [PDF - 132.70 KB ]