Environmental exposure to polychlorinated biphenyls and p,p'-DDE and sperm sex-chromosome disomy

Details

• Personal Author:
  Altshul LM ; Korrick SA ; McAuliffe ME ; Perry MJ ; Williams PL
• Description:
  BACKGROUND: Chromosomal abnormalities contribute substantially to reproductive problems, but the role of environmental risk factors has received little attention. OBJECTIVES: We evaluated the association of polychlorinated biphenyl (PCB) and dichlorodiphenyldichloroethylene (p,p'-DDE) exposures with sperm sex-chromosome disomy. METHODS: We conducted a cross-sectional study of 192 men from subfertile couples. We used multiprobe fluorescence in situ hybridization (FISH) for chromosomes X, Y, and 18 to determine XX, YY, XY, and total sex-chromosome disomy in sperm nuclei. Serum was analyzed for concentrations of 57 PCB congeners and p,p'-DDE. Poisson regression models were used to calculate incidence rate ratios (IRRs) for disomy by exposure quartiles, controlling for demographic characteristics and semen parameters. RESULTS: The median percent disomy was 0.3 for XX and YY, 0.9 for XY, and 1.6 for total sex-chromosome disomy. We observed a significant trend of increasing IRRs for increasing quartiles of p,p'-DDE in XX, XY, and total sex-chromosome disomy, and a significant trend of increasing IRRs for increasing quartiles of PCBs for XY and total sex-chromosome disomy; however, there was a significant inverse association for XX disomy. CONCLUSIONS: Our findings suggest that exposure to p,p'-DDE may be associated with increased rates of XX, XY, and total sex-chromosome disomy, whereas exposure to PCBs may be associated with increased rates of YY, XY, and total sex-chromosome disomy. In addition, we observed an inverse association between increased exposure to PCBs and XX disomy. Further work is needed to confirm these findings. [Description provided by NIOSH]
• Subjects:
  Chromosomes Environmental Exposure Ethylenes Genetics Men Occupational Exposure Occupational Health Polychlorinated Biphenyls Safety Sex Characteristics Spermatogenesis Urogenital Diseases Urogenital System

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• Keywords:
  Author Keywords: Aneuploidy Chlorodiphenyls Chromosome-damage Chromosome-disorders Dichlorodiphenyldichloroethylene (DDE) Dichlorodiphenyltrichloroethane (DDT) Disomy Employee-exposure Endocrine Disruptors Environmental-exposure Fertility Fluorescence Gene-mutation Genes In Situ Hybridization Pesticides Polychlorinated-biphenyls Polychlorinated Biphenyls (PCBs) Reproduction Reproductive-effects Reproductive-system Reproductive-system-disorders Sex-factors Sperm Spermatozoa

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• ISSN:
  0091-6765
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  District of Columbia ; Massachusetts ; OSHA Region 1 ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  120
• Issue:
  4
• NIOSHTIC Number:
  nn:20041247
• Citation:
  Environ Health Perspect 2012 Apr; 120(4):535-540
• Contact Point Address:
  M.J. Perry, Department of Environmental and Occupational Health, George Washington University School of Public Health and Health Services, 2100 M Street NW, Suite 203, Washington, DC 20037 USA
• Email:
  mperry@gwu.edu
• CAS Registry Number:
  1,1′-Biphenyl, chloro derivs. (CAS RN 1336-36-3) ; DDT (CAS RN 50-29-3) ; p,p′-DDE (CAS RN 72-55-9)
• Federal Fiscal Year:
  2012
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Health Perspectives
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a22e40b273cbc8bb0ada43d90926a4238297365888d50bba83cc423c1046912b9fe852c45dc878c643fe681909c9ada87aa626c0c40740a1cd3508df6563711b
• Download URL:
  https://stacks.cdc.gov/view/cdc/193852/cdc_193852_DS1.pdf
• File Type:
  [PDF - 195.64 KB ]