Chronic exposure to corticosterone enhances the neuroinflammatory and neurotoxic responses to methamphetamine

Bowyer JF; Kelly KA; Miller DB; O'Callaghan JP

i

Chronic exposure to corticosterone enhances the neuroinflammatory and neurotoxic responses to methamphetamine

Public Domain

2012/09/01
By Bowyer JF ; Kelly KA ; Miller DB ; ...

Details

Personal Author:

Bowyer JF ; Kelly KA ; Miller DB ; O'Callaghan JP
Description:

Upregulation of proinflammatory cytokines and chemokines in brain ("neuroinflammation") accompanies neurological disease and neurotoxicity. Previously, we documented a striatal neuroinflammatory response to acute administration of a neurotoxic dose of methamphetamine (METH), i.e. one associated with evidence of dopaminergic terminal damage and activation of microglia and astroglia. When we used minocycline to suppress METH-induced neuroinflammation, indices of dopaminergic neurotoxicity were not affected but suppression of neuroinflammation was incomplete. [Description provided by NIOSH]
Subjects:

Animals Laboratories Nervous System Nervous System Diseases Occupational Health Safety
Keywords:

Brain-function Corticosteroids Diseases Drugs Laboratory-animals Neurological-diseases Neurological-reactions Neurotoxic-effects Neurotoxicity
ISSN:

0022-3042
Document Type:

Text
Genre:

Journal Article
Place as Subject:

Arkansas ; OSHA Region 3 ; OSHA Region 6 ; West Virginia
CIO:

National Institute for Occupational Safety and Health (NIOSH)
Division:

HELD - Health Effects Laboratory Division
Topic:

Workplace Safety & Health
Location:

North America
Volume:

122
Issue:

5
NIOSHTIC Number:

nn:20041150
Citation:

J Neurochem 2012 Sep; 122(5):995-1009
Email:

jdo5@cdc.gov
CAS Registry Number:

Methamphetamine (CAS RN 537-46-2)
Federal Fiscal Year:

2012
NORA Priority Area:

Public Safety
Peer Reviewed:

True
Source Full Name:

Journal of Neurochemistry
Collection(s):

National Institute for Occupational Safety and Health
Main Document Checksum:

urn:sha-512:46d072bcf0f6f5e7b08f01789c40bce00ceddab118d66784b9866d6984124b5a7144d5fbe98b347a49a93b57da0c630fbc3c5a7add284e20f45b82d591ba9e6f
Download URL:

https://stacks.cdc.gov/view/cdc/193777/cdc_193777_DS1.pdf
File Type:

[PDF - 1.13 MB ]

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