Immunotoxicology of arc welding fume: worker and experimental animal studies

Details

• Personal Author:
  Antonini JM ; Erdely A ; Zeidler-Erdely PC
• Description:
  Arc welding processes generate complex aerosols composed of potentially hazardous metal fumes and gases. Millions of workers worldwide are exposed to welding aerosols daily. A health effect of welding that is of concern to the occupational health community is the development of immune system dysfunction. Increased severity, frequency, and duration of upper and lower respiratory tract infections have been reported among welders. Specifically, multiple studies have observed an excess mortality from pneumonia in welders and workers exposed to metal fumes. Although several welder cohort and experimental animal studies investigating the adverse effects of welding fume exposure on immune function have been performed, the potential mechanisms responsible for these effects are limited. The objective of this report was to review both human and animal studies that have examined the effect of welding fume pulmonary exposure on local and systemic immune responses. [Description provided by NIOSH]
• Subjects:
  Aerosols Air Pollutants, Occupational Animals Dust Laboratories Lung Men Metals Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Welding Women

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• Keywords:
  Aerosol-particles Animal-studies Arc-welding Author Keywords: Particulate Matter Epidemiology Gases Hazards Humans Immune Immune-system Immune-system-disorders Inhalation Laboratory-animals Metal-dusts Metal-fumes Metallic-compounds Metallic-dusts Metallic-fumes Pneumoconiosis Pulmonary-system Pulmonary-system-disorders Respiratory-infections Respiratory-system-disorders Risk-factors Welder Workers

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• ISSN:
  1547-691X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  411-425
• Volume:
  9
• Issue:
  4
• NIOSHTIC Number:
  nn:20041080
• Citation:
  J Immunotoxicol 2012 Oct-Dec; 9(4):411-425
• Contact Point Address:
  James M. Antonini, PhD, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road Mailstop 2015, Morgantown, WV 26505
• Email:
  jda6@cdc.gov
• Federal Fiscal Year:
  2013
• NORA Priority Area:
  Construction
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Immunotoxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a6a7204cb12c061f1cb93bff3ea67f9c711729d3899198dadaa25c3b4abc849cf21142362542ca7a13a758051f585e1713e55bd3985960ac0f0933bf3bb6e153
• Download URL:
  https://stacks.cdc.gov/view/cdc/193735/cdc_193735_DS1.pdf
• File Type:
  [PDF - 885.09 KB ]