An investigation of modifying effects of single nucleotide polymorphisms in metabolism-related genes on the relationship between peripheral nerve function and mercury levels in urine and hair

Details

• Personal Author:
  Basu N ; Franzblau, Alfred ; Gillespie B ; Goodrich JM ; Wang Y ; Werner R
• Description:
  Mercury (Hg) is a potent neurotoxicant. We hypothesized that single nucleotide polymorphisms (SNPs) in genes coding glutathione-related proteins, selenoproteins and metallothioneins may modify the relationship of mercury biomarkers with changes in peripheral nerve function. Dental professionals (n=515) were recruited in 2009 and 2010. Sensory nerve function (onset latency, peak latency and amplitude) of the median, ulnar and sural nerves was recorded. Samples of urine, hair and DNA were collected. Covariates related to demographics, nerve function and elemental and methyl-mercury exposure were also collected. Subjects included 244 dentists (47.4%) and 269 non-dentists (52.2%; mostly dental hygienists and dental assistants). The mean mercury levels in urine (1.06 µg/L) and hair (0.51 µg/g) were not significantly different from the US general population (0.95 µg/L and 0.47 µg/g, respectively). In multivariate linear models predicting nerve function adjusting for covariates, only 3 out of a total of 504 models showed stable and statistically significant interaction of SNPs with mercury biomarkers. Overall, given the possibility of false positives, the results suggested little evidence of effect modification of the SNPs on the relationship between mercury biomarkers with peripheral nerve function at exposure levels that are relevant to the general US population. [Description provided by NIOSH]
• Subjects:
  Biochemistry Biomarkers Dental Offices DNA Energy Metabolism Genetics Mercury Nervous System Nucleotides Occupational Health Poisoning Safety Sense Organs Urine

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• Keywords:
  Author Keywords: Mercury Biomarker Biochemical-indicators Dentistry Dentists DNA-damage Genes Glutathione Mathematical-models Mercury-compounds Mercury-poisoning Metabolism Metalloproteins Metallothionein Methyl-compounds Nerve-function Nerve Function Neurotoxins Peripheral-nervous-system Physiopathology Protein-biochemistry Proteins Sampling Selenoprotein Sensory-disorders Single Nucleotide Polymorphism Thiones Urinalysis

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• ISSN:
  0048-9697
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  32-38
• Volume:
  417
• Issue:
  2012
• NIOSHTIC Number:
  nn:20040981
• Citation:
  Sci Total Environ 2012 Feb; 417-418(2012):32-38
• Contact Point Address:
  Alfred Franzblau, M6023 SPH II, 1415 Washington Heights, University of Michigan School of Public Health, Ann Arbor, MI 48109-2029
• Email:
  afranz@umich.edu
• CAS Registry Number:
  Glutathione (CAS RN 70-18-8) ; Mercury (CAS RN 7439-97-6) ; Methylmercury(1+) (CAS RN 22967-92-6)
• Federal Fiscal Year:
  2012
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Science of the Total Environment
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:228449188f314a6c30033a8e4d35383aaeac5873806ce222bb2b1989ed22a79a3db7f8f32251db6d0494b8ed3d6857c8360af1d57fb9f0ae6727507678a653b5
• Download URL:
  https://stacks.cdc.gov/view/cdc/193661/cdc_193661_DS1.pdf
• File Type:
  [PDF - 210.57 KB ]