Pulmonary toxicity, distribution, and clearance of intratracheally instilled silicon nanowires in rats

Details

• Personal Author:
  Antonini JM ; Bangsaruntip S ; Castranova, Vincent ; Chapman RS ; Cohen GM ; Leonard, Stephen S. ; Mercer RR ; Roberts, Jennifer R. ; Scabilloni JF ; Schwegler-Berry D
• Description:
  Silicon nanowires (SiNWs) are being manufactured for use as sensors and transistors for circuit applications. The goal was to assess pulmonary toxicity and fate of Si NW using an in vivo experimental model. Male Sprague-Dawley rats were intratracheally instilled with 10, 25, 50, 100, or 250 microg of Si NW (approximately 20-30 nm diameter; approximately 2-15 microm length). Lung damage and the pulmonary distribution and clearance of Si NW were assessed at 1, 3, 7, 28, and 91 days after-treatment. Si NW treatment resulted in dose-dependent increases in lung injury and inflammation that resolved over time. At day 91 after treatment with the highest doses, lung collagen was increased. Approximately 70% of deposited Si NW was cleared by 28 days with most of the Si NW localized exclusively in macrophages. In conclusion, Si NW induced transient lung toxicity which may be associated with an early rapid particle clearance; however, persistence of Si NW over time related to dose or wire length may lead to increased collagen deposition in the lung. [Description provided by NIOSH]
• Subjects:
  Chemistry Environmental Monitoring Hazardous Substances Immune System Laboratories Lung Occupational Health Particulate Matter Respiratory System Risk Assessment Safety Silicon Compounds

  More +
• Keywords:
  Biological-effects Cell-biology Cellular-reactions Chemical-properties Chemical-reactions Dose-response Exposure-assessment Exposure-levels Exposure-methods Immune-reaction In-vivo-study Laboratory-animals Laboratory-testing Lung-cells Particulates Pulmonary-clearance Pulmonary-system Risk-analysis Silicon-compounds Toxic-effects

  More +
• ISSN:
  1687-4110
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2 ; OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  2012
• NIOSHTIC Number:
  nn:20040822
• Citation:
  J Nanomater 2012 May; 2012:398302
• Contact Point Address:
  Jenny R. Roberts, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
• Email:
  jur6@cdc.gov
• CAS Registry Number:
  Silicon (CAS RN 7440-21-3)
• Federal Fiscal Year:
  2012
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Nanomaterials
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:62d9f448f6257c757d37bd60b793b73620a12b7da23ebca01e35d138daedd9224f97e2d09351c231c4e649a43b1e2c80416b83a482c537e467ff006f75a50717
• Download URL:
  https://stacks.cdc.gov/view/cdc/193550/cdc_193550_DS1.pdf
• File Type:
  [PDF - 9.85 MB ]