On the correlation between single-frequency impedance measurements and human skin permeability to water

Details

• Personal Author:
  Bunge AL ; Horne A ; Navidi WC ; Orazem ME ; Roper CS ; Runciman J ; White EA
• Description:
  The objective of this study was to quantitatively compare measurements of tritiated water permeability with impedance determined at either 100 or 1000 Hz using an LCR databridge on the same pieces of skin. A previously published expression based on a simple circuit of a parallel resistor and constant phase element (CPE) was used to relate (RPARA) measured at different frequencies to the DC resistance (RskinA) and the steady-state skin permeability of tritiated water (kp). Using this analysis, kp and (RPARA) data from three laboratories were shown to be consistent with each other, and kp and (RskinA) estimated from (RPARA) were linearly correlated. Compared with urea and mannitol, which are known to permeate skin through a polar pathway, the value of kp for water was found to be about two times larger than expected for transport through only the polar pathway, suggesting an approximately equal contribution from the lipophilic pathway. Equations relating kp to (RPARA) and (RskinA) were used to compare on a consistent basis proposed tests for identifying and excluding damaged skin from chemical absorption studies. The criterion of 20 kO cm2 for (RskinA) corresponds to a tritiated water permeability of 3.2×10(-3) cm/h, which should exclude damaged skin without screening undamaged but higher permeability skin samples from study. [Description provided by NIOSH]
• Subjects:
  Aging Electricity Energy Metabolism Men Occupational Health Safety Skin Skin Absorption Women
• Keywords:
  Absorption-rates Age-groups Author Keywords: Electrical Impedance Spectroscopy Constant Phase Element Electrical-conductivity Humans In Vitro Mannitol Metabolism Polar Pathway Skin-absorption Skin Barrier Function Skin Integrity Stratum Corneum Tritiated Water Urea Water-sampling

  More +
• ISSN:
  0887-2333
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  25
• Issue:
  8
• NIOSHTIC Number:
  nn:20040640
• Citation:
  Toxicol In Vitro 2011 Dec; 25(8):2095-2104
• Contact Point Address:
  Annette L. Bunge, Chemical and Biological Engineering Department, Colorado School of Mines, Golden, CO 80401
• Email:
  abunge@mines.edu
• CAS Registry Number:
  Tritium (CAS RN 10028-17-8)
• Federal Fiscal Year:
  2012
• Performing Organization:
  Colorado School of Mines
• Peer Reviewed:
  True
• Start Date:
  20040901
• Source Full Name:
  Toxicology in Vitro
• End Date:
  20090331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:42cf596642a1ae405b7f97a251b56b4efec3a9f91ae59776c2ce67faf99bac8cc1a6ebc5a3477a167a8548e291fb42ce29d243515226caba69508c86fd57ca71
• Download URL:
  https://stacks.cdc.gov/view/cdc/193431/cdc_193431_DS1.pdf
• File Type:
  [PDF - 671.29 KB ]