Dermal absorption of finite doses of volatile compounds

Details

• Personal Author:
  Frasch, H. Fredrick
• Description:
  Laplace domain solutions to a previously published finite dose skin diffusion model are presented. The purpose of the current analysis is to derive a simple algebraic expression quantifying the total mass that is systemically absorbed at infinite time after exposure, relative to the applied mass. The resulting expression is a function of two dimensionless parameters: f, the fractional depth within the skin surface through which the permeant is initially deposited, and ?, the ratio of maximum evaporation flux to maximum dermal flux. The result may be useful for dermal risk assessment as well as in the evaluation of cosmetic and pharmaceutical product performance. [Description provided by NIOSH]
• Subjects:
  Occupational Health Risk Assessment Risk Factors Safety Skin Skin Absorption
• Keywords:
  Absorption Absorption-rates Author Keywords: Diffusion Diffusion-analysis Exposure-levels Exposure-limits Mathematical-models Mathematical Model Models Percutaneous Permeability Risk-analysis Risk-factors Skin-absorption Solvent Evaporation Volatiles

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• ISSN:
  0022-3549
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  101
• Issue:
  7
• NIOSHTIC Number:
  nn:20040635
• Citation:
  J Pharm Sci 2012 Jul; 101(7):2616-2619
• Contact Point Address:
  H. Frederick Frasch, Health Effects Laboratory, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505
• Email:
  hfrasch@cdc.gov
• Federal Fiscal Year:
  2012
• NORA Priority Area:
  Manufacturing ; Services
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Pharmaceutical Sciences
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:122eb6b02aa757816aff3836d6c515825a3551618570f8df90747e14c2544c785dda69ffdfaa3def17a6473e454a447dc1263bb8d0a4703bb7ebf1989e064741
• Download URL:
  https://stacks.cdc.gov/view/cdc/193426/cdc_193426_DS1.pdf
• File Type:
  [PDF - 102.60 KB ]