Lung pathologic findings in a local residential and working community exposed to World Trade Center dust, gas, and fumes

Details

• Personal Author:
  Abraham JL ; Berger KI ; Borczuk A ; Brusca-Augello G ; Caplan-Shaw CE ; Goldring RM ; Ko JP ; Moreira A ; Naidich DP ; Parsia SS ; Reibman J ; Rogers L ; Shiau MC ; Yee H
• Description:
  OBJECTIVE: To describe pathologic findings in symptomatic World Trade Center-exposed local workers, residents, and cleanup workers enrolled in a treatment program. METHODS: Twelve patients underwent surgical lung biopsy for suspected interstitial lung disease (group 1, n = 6) or abnormal pulmonary function tests (group 2, n = 6). High-resolution computed axial tomography and pathologic findings were coded. Scanning electron microscopy with energy-dispersive x-ray spectroscopy was performed. RESULTS: High-resolution computed axial tomography showed reticular findings (group 1) or normal or airway-related findings (group 2). Pulmonary function tests were predominantly restrictive. Interstitial fibrosis, emphysematous change, and small airway abnormalities were seen. All cases had opaque and birefringent particles within macrophages, and examined particles contained silica, aluminum silicates, titanium dioxide, talc, and metals. CONCLUSIONS: In symptomatic World Trade Center-exposed individuals, pathologic findings suggest a common exposure resulting in alveolar loss and a diverse response to injury. [Description provided by NIOSH]
• Subjects:
  Aging Air Pollutants, Occupational Air Pollution, Indoor Dust Environmental Exposure Lung Lung Diseases Men Metals Occupational Health Particulate Matter Pathology Respiratory System Respiratory Tract Diseases Safety Silicon Dioxide Talc Women

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• Keywords:
  Age-groups Air-contamination Airborne-dusts Airborne-fibers Airborne-particles Dust-explosions Dust-inhalation Dust-particles Dusts Environmental-exposure Exposure-levels Exposure-limits Fibrous-dusts Gases Humans Lung-disease Lung-disorders Lung-function Metal-dusts Metallic-dusts Particulate-dust Particulates Pathogens Pulmonary-function Pulmonary-system Pulmonary-system-disorders Respiratory-system-disorders Silica-dusts Talc-dust

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• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Grant ; Contract
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  53
• Issue:
  9
• NIOSHTIC Number:
  nn:20040288
• Citation:
  J Occup Environ Med 2011 Sep; 53(9):981-991
• Contact Point Address:
  Joan Reibman, MD, New York University School of Medicine, 550 1st Ave, Room NB-7N24, New York, NY 10016
• Email:
  joan.reibman@nyumc.org
• Federal Fiscal Year:
  2011
• Performing Organization:
  New York City Health and Hospitals Corporation
• Peer Reviewed:
  True
• Start Date:
  20080929
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  20110928
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f0b67b261b15983fd03c0ef82ed32ebc2923e4587534777ab1dab51103791431ecb675bba69a91051aaeaaea79c20102b8c05aed1b82fda92f038cd10a420cc4
• Download URL:
  https://stacks.cdc.gov/view/cdc/193221/cdc_193221_DS1.pdf
• File Type:
  [PDF - 679.72 KB ]