A pilot case-cohort study of liver and pancreatic cancers in poultry workers

Details

• Personal Author:
  Bangara S ; Felini M ; Johnson E ; Ndetan H ; Preacely N ; Sarda V
• Description:
  PURPOSE: To test the hypothesis that exposure to poultry oncogenic viruses that widely occurs occupationally in poultry workers and in the general population, may be associated with increased risks of deaths from liver and pancreatic cancers, and to identify new risk factors. METHODS: A pilot case-cohort study of both cancers within a combined cohort of 30,411 highly exposed poultry workers and 16,408 control subjects was conducted, and risk assessed by logistic regression odds ratios (OR) and proportional hazards risk ratios. RESULTS: New occupational findings were recorded respectively for pancreatic/liver cancers, for slaughtering of poultry (OR = 8.9, 95% confidence interval [CI]: 2.7-29.3)/OR = 9.1, 95% CI: 1.9-42.9); catching of live chickens (OR = 3.6, 95% CI: 1.2-10.9)/OR = 1.0, 95% CI: 0.1-8.5); killing other types of animals for food (OR = 4.8, 95% CI: 1.5-16.6)/OR = 2.0, 95% CI: 0.2-18.2), and ever worked on a pig raising farm (OR = 3.0, 95% CI: 1.0-8.2) for pancreatic cancer only. New non-occupational findings for liver cancer were for receiving immunization with yellow fever vaccine (OR = 8.7, 95% CI: 1.0-76.3); and vaccination with typhoid vaccine (OR = 6.3, 95% CI: 1.1-37.4). The study also confirmed previously reported risk factors for both diseases. CONCLUSIONS: This study provides preliminary evidence that exposure to poultry oncogenic viruses may possibly be associated with the occurrence of liver and pancreatic cancers. Case-control studies nested within occupational cohorts of highly exposed subjects of sufficient statistical power may provide an efficient and valid method of investigating/confirming these findings. [Description provided by NIOSH]
• Subjects:
  Agriculture Animal Husbandry Animals Case Reports Digestive System Digestive System Diseases Epidemiology Food Industry Liver Livestock Mortality Neoplasms Occupational Health Risk Assessment Risk Factors Safety Viral Diseases

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• Keywords:
  Agricultural-workers Animal-husbandry Animal-husbandry-workers Author Keywords: Oncogenic Viruses Cancer Cancer-rates Case-studies Liver-damage Liver-disorders Mortality-data Mortality-rates Occupation Oncogenic-agents Pancreas Poultry Poultry-industry Poultry-workers Risk-analysis Risk-factors Slaughterhouses Statistical-analysis Vaccines Viral-infections

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• ISSN:
  1047-2797
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 6 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  21
• Issue:
  10
• NIOSHTIC Number:
  nn:20040140
• Citation:
  Ann Epidemiol 2011 Oct; 21(10):755-766
• Contact Point Address:
  Dr. Eric S. Johnson, PhD, Department of Epidemiology, School of Public Health, UNT Health Sciences Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107
• Email:
  Eric.Johnson@unthsc.edu
• Federal Fiscal Year:
  2012
• Performing Organization:
  University of North Texas
• Peer Reviewed:
  True
• Start Date:
  20050901
• Source Full Name:
  Annals of Epidemiology
• End Date:
  20080430
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b47f3be9de6b955a3df7a9568922c7d25a543aeb0b87a9295bfb7632fcb4e28c7a8a93756c24ea28bc0e9002ee9fbc9ed11da611c4c404e6bd19e13021996c85
• Download URL:
  https://stacks.cdc.gov/view/cdc/193106/cdc_193106_DS1.pdf
• File Type:
  [PDF - 115.08 KB ]