Manganese accumulation in nail clippings as a biomarker of welding fume exposure and neurotoxicity

Details

• Personal Author:
  Andrews, Ronnee N. ; Antonini JM ; Jefferson AM ; Kashon ML ; Lin GX ; Roberts, Jennifer R. ; Sriram K
• Description:
  Occupational exposure to welding fumes (WF) is thought to cause Parkinson's disease (PD)-like neurological dysfunction. An apprehension that WF may accelerate the onset of PD also exists. Identifying reliable biomarkers of exposure and neurotoxicity are therefore critical for biomonitoring and neurological risk characterization of WF exposure. Manganese (Mn) in welding consumables is considered the causative factor for the neurological deficits seen in welders. Hence, we sought to determine if Mn accumulation in blood or nail clippings can be a marker for adverse exposure and neurotoxicity. To model this, rats were exposed by intratracheal instillation to dissolved or suspended fume components collected from gas metal arc-mild steel (GMA-MS) or manual metal arc-hard surfacing (MMA-HS) welding. Trace element analysis revealed selective Mn accumulation in dopaminergic brain areas, striatum (STR) and midbrain (MB), following exposure to the two fumes. This caused dopaminergic abnormality as evidenced by loss of striatal tyrosine hydroxylase (Th; 25 - 32% decrease) and Parkinson disease (autosomal recessive, early onset) 7 (Park7; 25 - 46% decrease) proteins. While blood Mn was not detectable, Mn levels in nails strongly correlated with the pattern of Mn accumulation in the striatum (R2 = 0.9386) and midbrain (R2 = 0.9332). Exposure to manganese chloride (MnCl2) caused similar Mn accumulation in STR, MB and nail. Our findings suggest that nail Mn has the potential to be a sensitive and reliable biomarker for longterm Mn exposure and associated neurotoxicity. The non-invasive means by which nail clippings can be collected, stored, and transported with relative ease, make it an attractive surrogate for biomonitoring WF exposures in occupational settings. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Biomarkers Cardiovascular System Epidemiology Hazardous Substances Laboratories Manganese Nervous System Nervous System Diseases Occupational Health Risk Assessment Risk Factors Safety Welding Workplace

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• Keywords:
  Author Keywords: Biomarker Biological-effects Biomonitoring Brain Brain-disorders Brain-electrical-activity Brain-function Cerebrovascular-system Disease-incidence Fumes Health-hazards Laboratory-animals Laboratory-testing Nail Nerve-function Nervous-system-disorders Neurological-diseases Neurological-reactions Neurological-system Neuromotor-system Neuromotor-system-disorders Neurotoxic-effects Neurotoxicity Neurotoxicology Occupational Exposures Parkinsonism Parkinsons Disease Risk-analysis Risk-factors Statistical-analysis Welder Welders Welding-industry Welding Fume Workplace-monitoring Workplace-studies Workplace Monitoring

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• ISSN:
  0300-483X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 3 ; OSHA Region 5 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  73-82
• Volume:
  291
• Issue:
  1
• NIOSHTIC Number:
  nn:20039971
• Citation:
  Toxicology 2012 Jan; 291(1-3):73-82
• Contact Point Address:
  Krishnan Sriram, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505
• Email:
  edwin_van_wijngaarden@urmc.rochester.edu
• CAS Registry Number:
  Manganese (CAS RN 7439-96-5)
• Federal Fiscal Year:
  2012
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Toxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:77d345e7fddf1e1f3a9c7a066d7ed77038a6c85d52d0cd061ac6a1706d2c9dff8577f0815f6a7c3268e684f636e0e0338820d8221c5df711d0930e3efa06d138
• Download URL:
  https://stacks.cdc.gov/view/cdc/192997/cdc_192997_DS1.pdf
• File Type:
  [PDF - 989.87 KB ]