Development of a sampling patch to measure dermal exposures to monomeric and polymeric 1,6-hexamethylene diisocyanate: a pilot study

Details

• Personal Author:
  Fent, Kenneth W. ; Nylander-French LA ; Thomasen JM
• Description:
  The purpose of this study was to develop and evaluate a patch sampler to monitor dermal exposures to monomeric and polymeric 1,6-hexamethylene diisocyanate (HDI) in the automotive refinishing industry. Different patch materials were used to construct the patches, and patches impregnated with a derivatizing solution were compared with those that were not impregnated. We observed that impregnated felt patches measured significantly more HDI monomer (p = 0.04) than non-impregnated patches in a controlled experiment. Both impregnated and non-impregnated patches were compared with the tape-strip method by monitoring three spray painters' dermal exposure to monomeric and polymeric HDI. Isocyanurate was the predominant species measured by all three sampler types with detectable levels in greater than 86 percent of samples. Overall, tape-strips of exposed skin measured lower levels of monomeric and polymeric HDI than impregnated patch samplers at the same sampling site on the skin. Unlike tape-strips, impregnated patches are not as prone to evaporative or reactive losses or losses due to rapid penetration into the skin. Further investigations are warranted to evaluate these and other methods to measure dermal exposure to workers under occupational conditions to better understand the relationship between dermal exposure and internal dose. [Description provided by NIOSH]
• Subjects:
  Automobiles Environmental Monitoring Isocyanates Occupational Health Polymers Safety Skin
• Keywords:
  Author Keywords: 1,6-hexamethylene Diisocyanate (HDI) Automobile-repair-shops Dermal Exposure Dermal Sampling Exposure-assessment Measurement-equipment Monomers Patch-tests Polyisocyanate Samplers Sampling-methods Sampling Method Skin-exposure

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• ISSN:
  1545-9624
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  North Carolina ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  8
• Issue:
  12
• NIOSHTIC Number:
  nn:20039966
• Citation:
  J Occup Environ Hyg 2011 Dec; 8(12):709-717
• Contact Point Address:
  Leena A. Nylander-French, Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, CB #7431, Rosenau Hall, Chapel Hill, NC 27599-7431
• Email:
  leena_french@unc.edu
• CAS Registry Number:
  Hexamethylene diisocyanate (CAS RN 822-06-0)
• Federal Fiscal Year:
  2012
• Performing Organization:
  University of North Carolina, Chapel Hill
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Occupational and Environmental Hygiene
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8842edf7c64657d12aa0234f05236204ccd0f052712050a7d2aaed29d52d7597c11180a317fcaff73b150ca43f67210d107c87fcc9b1046660cf785dd3321828
• Download URL:
  https://stacks.cdc.gov/view/cdc/192993/cdc_192993_DS1.pdf
• File Type:
  [PDF - 323.16 KB ]