In utero exposure to bisphenol-A and its effect on birth weight of offspring

Details

• Personal Author:
  He X ; Li DK ; Miao M ; Yuan W ; Zhu G
• Description:
  To examine the effect of in utero BPA exposure on the birth weight of offspring, a total of 587 children from families in which parent(s) did or did not have occupational exposure to BPA were examined. Their birth weights were obtained by an in-person interview of the mother. Parental BPA exposure level during the index pregnancy was determined through personal air sampling measurements and exposure history. After controlling for potential confounders, parental exposure to BPA in the workplace during pregnancy was associated with decreased birth weight. The association was stronger for maternal exposure which is statistically significant (P=0.02). A dose-response relationship was observed with increased BPA exposure levels in pregnancy associated with greater magnitude of decrease of birth weight in offspring (P=0.003). Our findings provide the new epidemiologic evidence suggesting that in utero exposure to BPA during pregnancy may be associated with decreased birth weight in offspring. [Description provided by NIOSH]
• Subjects:
  Endocrine System Environmental Monitoring Epidemiology Family Occupational Exposure Occupational Health Phenol Pregnancy Safety Urogenital Diseases Urogenital System

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• Keywords:
  Air-sampling Author Keywords: Birth Weight Birth-defects Children Dose-response Endocrine-function Endocrine-system Endocrine Disruptor Exposure-assessment Families In-utero-study In Utero Exposure Occupational Exposure Phenols Prenatal-exposure Reproduction Reproductive-effects Reproductive-hazards Weight-factors

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• ISSN:
  0890-6238
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  64-68
• Volume:
  32
• Issue:
  1
• NIOSHTIC Number:
  nn:20039962
• Citation:
  Reprod Toxicol 2011 Jul; 32(1):64-68
• Contact Point Address:
  De-Kun Li, Division of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA 94612, USA
• Email:
  yuanwei11@yahoo.com
• CAS Registry Number:
  2,2-Bis(4-hydroxyphenyl)propane (CAS RN 80-05-7)
• Federal Fiscal Year:
  2011
• Performing Organization:
  Kaiser Foundation Research Institute
• Peer Reviewed:
  True
• Start Date:
  20030930
• Source Full Name:
  Reproductive Toxicology
• End Date:
  20110929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1a6d2bdc6a72ed7113c638b59b6911b10cc5e527cbf2a1030133b4315f1b555357ebb5abcae241e5979380fab459fdd3103d4684ba29cd131c0281b567f75b45
• Download URL:
  https://stacks.cdc.gov/view/cdc/192989/cdc_192989_DS1.pdf
• File Type:
  [PDF - 199.28 KB ]