Dermal penetration potential of perfluorooctanoic acid (PFOA) in human and mouse skin

Details

• Personal Author:
  Anderson, Stacey E. ; Barbero AM ; Franko J ; Frasch, H. Fredrick ; Meade BJ
• Description:
  Recent data, using a murine model, have indicated that dermal exposure to perfluorooctanoic acid (PFOA) induces immune modulation, suggesting that this may be an important route of PFOA exposure. To investigate the dermal penetration potential of PFOA, serum concentrations were analyzed in mice following topical application. Statistically significant and dose-responsive increases in serum PFOA concentrations were identified. In vitro dermal penetration studies also demonstrated that PFOA permeates both mouse and human skin. Investigation into the mechanisms mediating PFOA penetration demonstrated that dermal absorption was strongly dependent upon the ionization status of PFOA. In addition, PFOA solid, but not 1% PFOA/acetone solution, was identified as corrosive using a cultured epidermis in vitro model. Despite its corrosive potential, expression of inflammatory cytokines in the skin of topically exposed mice was not altered. These data suggest that PFOA is dermally absorbed and that under certain conditions the skin may be a significant route of exposure. [Description provided by NIOSH]
• Subjects:
  Acetone Animals Corrosion Environmental Exposure Laboratories Occupational Health Risk Assessment Risk Factors Safety Skin Skin Absorption

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• Keywords:
  Acetones Biological-effects Corrosives Cytokines Dermal Absorption Dermal Exposures Exposure Levels In Vitro Studies In Vitro Study Ionization Laboratory-animals Laboratory-testing Models Physical-reactions Physiological-response Physiological-testing Risk Factors Skin-absorption Skin-exposure Skin-irritants Skin-sensitivity Skin-tests Statistical-analysis

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• ISSN:
  1528-7394
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  50-62
• Volume:
  75
• Issue:
  1
• NIOSHTIC Number:
  nn:20039896
• Citation:
  J Toxicol Environ Health A 2012 Jan; 75(1):50-62
• Contact Point Address:
  Stacey E. Anderson, PhD, NIOSH, 1095 Willowdale Road, Morgantown, WV 26505
• Email:
  Sanderson4@cdc.gov
• Federal Fiscal Year:
  2012
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  West Virginia University
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Toxicology and Environmental Health, Part A: Current Issues
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c0adf41b998b0be150e18647b01ce23e7de46e89d7dafc2700d3259749f7031330fab43d7863980aa303fcd8262161687c091ef1f0b48b3b9c12bc4c1299fcb6
• Download URL:
  https://stacks.cdc.gov/view/cdc/192956/cdc_192956_DS1.pdf
• File Type:
  [PDF - 482.26 KB ]