Diabetes, impaired glucose tolerance, and metabolic biomarkers in individuals with normal glucose tolerance are inversely associated with lung function: The Jackson Heart Study

Details

• Personal Author:
  Burchfiel CM ; Harrison K ; Hickson DA ; Liu J-K ; Petrini MF ; Sarpong DF ; White WB
• Description:
  The objectives of this study were to test the hypothesis that diabetes and impaired glucose tolerance (IGT), diabetes control and diabetes duration, and metabolic biomarkers in adults with normal glucose tolerance (NGT) are inversely associated with spirometry-measured lung function. We conducted a cross-sectional observational cohort study that included nonsmoking African American adults (n = 2,945; mean age = 52.5 + / - 12.6 years; 69.2 percent female), who were free of cardiovascular disease, from the Jackson Heart Study. The interventions were diabetes, metabolic biomarkers and lung function. We measured the associations of glycemia with forced expiratory volume (FEV) in 1 s, FEV in 6 s, and vital capacity. Multivariable adjusted mean lung function values were lower among adults with diabetes and IGT (in women only, but not after adjustment for waist circumference) than adults with NGT. Among adults with diabetes, no associations were observed between lung function and diabetes control or duration. In women with NGT, lower lung function was consistently associated with higher glucose levels and less consistently with higher insulin levels and insulin resistance. Lower lung function was consistently associated with higher insulin levels and insulin resistance and less consistently associated with insulin and hemoglobin A1c in men with NGT. Overall, our findings generally support the hypothesis that diabetes, IGT, and increased levels of metabolic biomarkers in individuals with NGT are inversely associated with lung function in African Americans, independent of adiposity. [Description provided by NIOSH]
• Subjects:
  Biomarkers Energy Metabolism Lung Men Occupational Health Race Factors Respiratory Function Tests Respiratory System Safety Women
• Keywords:
  Author Keywords: Forced Expiratory Volume In 1 S Biological-effects Biological-function Breathing Impaired Glucose Tolerance Insulin Resistance Lung-function Metabolic-activation Metabolic-disorders Metabolic-rate Metabolic-study Metabolism Pulmonary-function Pulmonary-function-tests Racial-factors Respiration Respiratory-function-tests Respiratory-rate Spirometry Sugars Vital-capacity Vital Capacity

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• ISSN:
  0341-2040
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Mississippi ; OSHA Region 3 ; OSHA Region 4 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  311-321
• Volume:
  189
• Issue:
  4
• NIOSHTIC Number:
  nn:20039633
• Citation:
  Lung 2011 Aug; 189(4):311-321
• Contact Point Address:
  D. A. Hickson, Jackson State University, Jackson Heart Study, 350 W Woodrow Wilson Ave., Suite 701, Jackson, MS 39213 USA
• Email:
  demarc.a.hickson@jsums.edu
• Federal Fiscal Year:
  2011
• Peer Reviewed:
  True
• Source Full Name:
  Lung
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:95ddc9e5c9ff76d739232a44fad302496f3337347cf2f9ed5a9ec352413b3ee9ded1d3ed1783ffa713d686b60652e6730d98923698fe7e4b07c0c4ad9df76b30
• Download URL:
  https://stacks.cdc.gov/view/cdc/192805/cdc_192805_DS1.pdf
• File Type:
  [PDF - 210.80 KB ]