Sarcoidosis diagnosed after September 11, 2001, among adults exposed to the World Trade Center disaster

Details

• Personal Author:
  Cone, James E. ; Jordan HT ; Osahan SS ; Prezant D ; Stellman SD ; Teirstein A
• Description:
  Objective: Explore relationships between World Trade Center (WTC) exposures and sarcoidosis. Methods: Sarcoidosis has been reported after exposure to the WTC disaster. We ascertained biopsy-proven post-9/11 sarcoidosis among WTC Health Registry enrollees. Cases diagnosed after Registry enrollment were included in a nested case-control study. Controls were matched to cases on age, sex, race or ethnicity, and eligibility group (eg, rescue or recovery worker). Results: We identified 43 cases of post-9/11 sarcoidosis. Twenty-eight incident cases and 109 controls were included in the case-control analysis. Working on the WTC debris pile was associated with sarcoidosis (odds ratio 9.1, 95 percent confidence interval 1.1 to 74.0), but WTC dust cloud exposure was not (odds ratio 1.0, 95 percent confidence interval 0.4 to 2.8). Conclusions: Working on the WTC debris pile was associated with an elevated risk of post-9/11 sarcoidosis. Occupationally exposed workers may be at increased risk. [Description provided by NIOSH]
• Subjects:
  Case Reports Cells, Cultured Demography Emergencies Emergency Responders Environmental Monitoring Eye Immune System Lung Occupational Exposure Occupational Health Respiratory System Risk Assessment Risk Factors Safety Sense Organs Skin

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• Keywords:
  Biological-effects Biological-monitoring Biopsy Case-studies Cell-alteration Cell-cultures Cell-damage Cell-function Corticosteroids Demographic-characteristics Disease-incidence Emergency-responders Emergency-response Employee-exposure Employee-health Exposure-assessment Eyes Immune-reaction Immune-system Immune-system-disorders Lymph-nodes Organs Rescue-workers Risk-analysis Risk-factors Tissue-disorders

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• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Cooperative Agreement ; Contract
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  53
• Issue:
  9
• NIOSHTIC Number:
  nn:20039616
• Citation:
  J Occup Environ Med 2011 Sep; 53(9):966-974
• Contact Point Address:
  Hannah T. Jordan, MD, or James E. Cone, MD, World Trade Center Health Registry, New York City Department of Health and Mental Hygiene, 42-09 28th St, 7th floor, Long Island City, NY 11101
• Email:
  hjordan1@health.nyc.gov
• Federal Fiscal Year:
  2011
• Performing Organization:
  New York City Fire Department
• Peer Reviewed:
  True
• Start Date:
  20040701
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  20110630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:643fd5bcde3ea923d81747ec908c9853c117f36ca3068d0c58ff127b8b1736c914014f550547e4c9c99c7863796f1e089e25f732c455d58b3fa85395cbe0a5e5
• Download URL:
  https://stacks.cdc.gov/view/cdc/192794/cdc_192794_DS1.pdf
• File Type:
  [PDF - 224.12 KB ]