Lab-on-a-chip sensor for detection of highly electronegative heavy metals by anodic stripping voltammetry

Details

• Personal Author:
  Haynes EN ; Heineman WR ; Herren J ; Jothimuthu P ; Papautsky I ; Wilson RA
• Description:
  This work describes development of a lab-on-a-chip sensor for electrochemical detection of highly electronegative heavy metals such as manganese and zinc by anodic stripping voltammetry. The sensor consists of a three-electrode system, with a bismuth working electrode, a Ag/AgCl reference electrode, and a Au auxiliary electrode. Hydrolysis at the auxiliary electrode is a critical challenge in such electrochemical sensors as its onset severely limits the ability to detect electronegative metals. The bismuth working electrode is used due to its comparable negative detection window and reduced toxicity with respect to a conventional mercury electrode. Through optimization of the sensor layout and the working electrode surface, effects of hydrolysis were substantially reduced and the potential window was extended to the -0.3 to -1.9 V range (vs. Ag/AgCl reference electrode), which is far more negative than what is possible with conventional Au, Pt, or carbon electrodes. The described lab-on-a-chip sensor for the first time permits reliable and sensitive detection of the highly electronegative manganese. The favorable performance of the bismuth electrode coupled with its environmentally-friendly nature make the described sensor attractive for applications where disposable chips are desirable. With further development and integrated sample preparation, the lab-on-a-chip may be converted into a point-of-care platform for monitoring heavy metals in blood (e.g., assessment of manganese exposure). [Description provided by NIOSH]
• Subjects:
  Blood Computers Electrical Equipment And Supplies Hematologic Tests Laboratories Manganese Metals Metals, Heavy Occupational Health Safety Zinc Compounds

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• Keywords:
  Anodic Stripping Voltammetry Author Keywords: Electrochemical Sensor Biological-monitoring Bismuth Electrodes Blood-samples Blood-sampling Computer-equipment Detectors Electrochemistry Electronic-devices Heavy-metals Heavy Metal Detection Lab-on-a-chip Laboratory-equipment Laboratory-techniques Manganese-compounds Metal-compounds Sample-preparation Sampling-equipment Sampling-methods Zinc-compounds

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• ISSN:
  1387-2176
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  13
• Issue:
  4
• NIOSHTIC Number:
  nn:20039582
• Citation:
  Biomed Microdevices 2011 Aug; 13(4):695-703
• Contact Point Address:
  Ian Papautsky, BioMicroSystems Laboratory, School of Electronics and Computing Systems, 814 Rhodes Hall, ML030, University of Cincinnati, Cincinnati, OH 45221, USA
• Email:
  Ian.Papautsky@uc.edu
• CAS Registry Number:
  Bismuth (CAS RN 7440-69-9) ; Manganese (CAS RN 7439-96-5) ; Zinc (CAS RN 7440-66-6)
• Federal Fiscal Year:
  2011
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  False
• Start Date:
  20050701
• Source Full Name:
  Biomedical Microdevices
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8eead8e9c892dc19ddb3598b0300f29b01b2ca518257b54f643d6f88a8c899ac08d0ff3404422452474d1b0751fbd500fb13df710deb2548c695fdd1d0594cbd
• Download URL:
  https://stacks.cdc.gov/view/cdc/192773/cdc_192773_DS1.pdf
• File Type:
  [PDF - 703.80 KB ]