Toenail, blood, and urine as biomarkers of manganese exposure

Details

• Personal Author:
  Cavallari JM ; Christiani, David C. ; Fang SC ; Herrick, Robert F. ; Laohaudomchok W ; Lin X ; Weisskopf MG
• Description:
  Objective: This study examined the correlation between manganese exposure and manganese concentrations in different biomarkers. Methods: Air measurement data and work histories were used to determine manganese exposure over a work shift and cumulative exposure. Toenail samples (n = 49), as well as blood and urine before (n = 27) and after (urine, n = 26; blood, n = 24) a work shift were collected. Results: Toenail manganese, adjusted for age and dietary manganese, was significantly correlated with cumulative exposure in 7 to 9, 10 to 12, and 7 to 12 months before toenail clipping date, but not 1 to 6 months. Manganese exposure over a work shift was not correlated with changes in blood nor urine manganese. Conclusions: Toenails appeared to be a valid measure of cumulative manganese exposure 7 to 12 months earlier. Neither change in blood nor urine manganese appeared to be suitable indicators of exposure over a typical work shift. [Description provided by NIOSH]
• Subjects:
  Biomarkers Construction Industry Environmental Monitoring Hazardous Substances Manganese Occupational Health Safety
• Keywords:
  Cell-biology Cellular-reactions Construction Construction-industry Construction-workers Exposure-assessment Exposure-levels Health-hazards Manganese-compounds Mathematical-models Physical-reactions Physiological-response Reaction-rates Statistical-analysis

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• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Grant ; Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; Maryland ; Massachusetts ; OSHA Region 1 ; OSHA Region 3 ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  53
• Issue:
  5
• NIOSHTIC Number:
  nn:20039539
• Citation:
  J Occup Environ Med 2011 May; 53(5):506-510
• Contact Point Address:
  Wisanti Laohaudomchok, ScD, Department of Environmental Health, Harvard School of Public Health, Landmark Center, 3rd Floor-E, 401 Park Dr, Boston, MA 02215
• Email:
  wisanti@post.harvard.edu
• CAS Registry Number:
  Manganese (CAS RN 7439-96-5)
• Federal Fiscal Year:
  2011
• NORA Priority Area:
  Construction
• Performing Organization:
  CPWR - The Center for Construction Research and Training, Silver Spring, Maryland
• Peer Reviewed:
  True
• Start Date:
  20090901
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  20240831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d2b37bb49e55dc99bdc9c2d341161e83f4ebc407f8b3cc2d1a3149bc6c9b6b498f26439bef37caa25a80855d43c41cc7597e9bb0a3bec180ebcfe8c77c9bd1a5
• Download URL:
  https://stacks.cdc.gov/view/cdc/192740/cdc_192740_DS1.pdf
• File Type:
  [PDF - 99.71 KB ]