Factors governing pulmonary response to inhaled particulate matter

Details

• Personal Author:
  Castranova, Vincent
• Description:
  The pulmonary response to an inhaled particle is influenced by its deposition fraction and the site of deposition. Pulmonary response would be minimized if the particle were rapidly cleared and be more pronounced if the particle had a high residence time in the lung. Once in the lung, the unique surface properties of a particle govern particle-cell interactions and affect the bioactivity and degree of pathogenicity of the particle. Nanoparticles are likely to exhibit greater adverse health effects than fine particles of the same composition due to their higher pulmonary deposition, their ability to enter the alveolar septa and perhaps the systemic circulation, and the role of particle surface area in affecting cellular toxicity. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Biological Factors Hazardous Substances Irritants Lung Lung Diseases Occupational Health Particulate Matter Respiratory Hypersensitivity Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Airborne-particles Author Keywords: Factors Biohazards Biological-effects Biological-factors Biological-function Biological-systems Cell-biology Cell-function Cellular-function Cellular-reactions Deposition Site And Lung Burden Health-hazards Influencing Bioactivity - Diameter Lung-cells Lung-disorders Lung-irritants Nanotechnology Particle-aerodynamics Particle Characteristics Particulate-dust Particulates Physiological-chemistry Physiological-effects Physiological-function Physiological-response Pulmonary-function Pulmonary-system Pulmonary-system-disorders Pulmonary Response To Inhaled Particles - Influenced By Deposition Fraction And Deposition Site Pulmonary Response To Inhaled Particulate Matter - Physiochemical Properties Of Particles Respiratory-hypersensitivity Respiratory-irritants Respiratory-system-disorders Toxic-effects

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• ISBN:
  9780470387412
• Publisher:
  John Wiley and Sons, Inc
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  New Jersey ; OSHA Region 2 ; OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20039273
• Citation:
  Aerosol measurement: principles, techniques, and applications, third edition. Kulkarni P, Baron PA, Willeke K, eds. Hoboken, NJ: John Wiley and Sons, Inc, 2011 Jan; :793-803
• Editor(s):
  Kulkarni P; Baron PA; Willeke K
• Federal Fiscal Year:
  2011
• Peer Reviewed:
  False
• Source Full Name:
  Aerosol measurement: principles, techniques, and applications, third edition
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e633167ed9df52c091a811b30ec6e91761f30c5c5d3a51569c395b8329f443e74ca6a15e1866dbde470ddca2f13ef6afd46d9db14294b6b8f2a8a9d12939f275
• Download URL:
  https://stacks.cdc.gov/view/cdc/192657/cdc_192657_DS1.pdf
• File Type:
  [PDF - 261.58 KB ]