The multiple functions of cytochrome c and their regulation in life and death decisions of the mammalian cell: from respiration to apoptosis

Details

• Personal Author:
  Doan JW ; Huttemann M ; Kagan VE ; Lee I ; Pecina P ; Rainbolt M ; Samavati L ; Sanderson TH
• Description:
  Cytochrome c (Cytc) is essential in mitochondrial electron transport and intrinsic type II apoptosis. Mammalian Cytc also scavenges reactive oxygen species (ROS) under healthy conditions, produces ROS with the co-factor p66(Shc), and oxidizes cardiolipin during apoptosis. The recent finding that Cytc is phosphorylated in vivo underpins a model for the pivotal role of Cytc regulation in making life and death decisions. An apoptotic sequence of events is proposed involving changes in Cytc phosphorylation, increased ROS via increased mitochondrial membrane potentials or the p66(Shc) pathway, and oxidation of cardiolipin by Cytc followed by its release from the mitochondria. Cytc regulation in respiration and cell death is discussed in a human disease context including neurodegenerative and cardiovascular diseases, cancer, and sepsis. [Description provided by NIOSH]
• Subjects:
  Cardiovascular Diseases Cardiovascular System Cells, Cultured Neoplasms Occupational Health Safety
• Keywords:
  Apoptosis Author Keywords: Aging Cancer Cardiolipin Cardiovascular-disease Cardiovascular-system-disease Cell-biology Cell-cultures Cell-damage Cell-function Cell Signaling Cytochrome C Mammalian-cells Oxidative Phosphorylation Reactive Oxygen Species

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• ISSN:
  1567-7249
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; OSHA Region 3 ; OSHA Region 5 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  369-381
• Volume:
  11
• Issue:
  3
• NIOSHTIC Number:
  nn:20039193
• Citation:
  Mitochondrion 2011 May; 11(3):369-381
• Contact Point Address:
  Petr Pecina, Institute of Physiology and Center for Applied Genomics, Academy of Sciences of the Czech Republic, Vídenská 1083, Prague, Czech Republic
• CAS Registry Number:
  Cytochrome c (CAS RN 9007-43-6)
• Federal Fiscal Year:
  2011
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  University of Pittsburgh at Pittsburgh
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Mitochondrion
• End Date:
  20160630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:42c8690a0961bb9d6379dcfad5ac47c6441cd33c21c0816760eb2ffd67f643ae1bcbeadaf103155dc98e5e3f58b71a83e21f11d341dee799dfb007f078084a58
• Download URL:
  https://stacks.cdc.gov/view/cdc/192631/cdc_192631_DS1.pdf
• File Type:
  [PDF - 394.43 KB ]