Toll-like and adenosine receptor expression in injured skeletal muscle

Details

• Personal Author:
  Hulderman T ; Liston A ; Simeonova PP ; Warren GL
• Description:
  Introduction: Many aspects of skeletal muscle regeneration are now considered to be controlled by the innate immune system, specifically macrophages, but the mechanisms for activation and modulation of the innate immune system during injury are not well understood. Methods: We analyzed the expression of toll-like receptors (TLRs) and adenosine receptors during traumatic skeletal muscle injury. mRNA expression and immunostaining of these receptors were evaluated in mouse skeletal muscle injured by freezing. Results: Expression of nearly all mammalian TLRs was induced at 1 and/or 3 days postinjury with a common trend for higher expression at day 3. Injury also elicited a dramatic increase in the expression of adenosine receptors A(2B) and A(3) but not A(1) and A(2A). Conclusions: Both receptor types may be potential targets for stimulation of skeletal muscle tissue regeneration and functional restoration after injury. [Description provided by NIOSH]
• Subjects:
  Animals Biomechanical Phenomena Cumulative Trauma Disorders Fatigue Immune System Laboratories Musculoskeletal Diseases Musculoskeletal System Occupational Health Risk Assessment Risk Factors Safety

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• Keywords:
  Animal-studies Author Keywords: Damage Biomechanics Cumulative-trauma-disorders Immune-reaction Immune-system Inflammation Innate Immune System Laboratory-animals Laboratory-testing Macrophages Musculoskeletal-system Musculoskeletal-system-disorders Physiological-effects Physiological-factors Physiological-fatigue Physiological-measurements Physiological-response Regeneration Rest-periods Risk-factors Traumatic-injuries

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• ISSN:
  0148-639X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; OSHA Region 3 ; OSHA Region 4 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  85-92
• Volume:
  44
• Issue:
  1
• NIOSHTIC Number:
  nn:20039030
• Citation:
  Muscle Nerve 2011 Jul; 44(1):85-92
• Contact Point Address:
  Gordon L. Warren, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, HELD, 1095 Willowdale Rd., MS H-2800, Morgantown, WV 26505
• Email:
  gwarren@gsu.edu
• Federal Fiscal Year:
  2011
• Peer Reviewed:
  True
• Source Full Name:
  Muscle & Nerve
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f211392beecf01e1d271b46693fe2b8661f260b0fa0d00c5ba10369cc8e3121e3aa2f30dea570a35693ecc895e5f521c03dfd359f3725d749be35a06df2a6393
• Download URL:
  https://stacks.cdc.gov/view/cdc/192524/cdc_192524_DS1.pdf
• File Type:
  [PDF - 484.20 KB ]