Allergic potential and immunotoxicity induced by topical application of 1-chloro-4-(trifluoromethyl) benzene (PCBTF) in a murine model

Details

• Personal Author:
  Anderson, Stacey E. ; Franko J ; Jackson LG ; Meade BJ
• Description:
  The purpose of the studies in this paper was to evaluate the allergic potential, immunotoxicity, and irritancy of the occupationally relevant chemical, 1-chloro-4-(trifluoromethyl)benzene, also known as parachlorobenzotrifluoride (PCBTF), following dermal exposure in a murine model. Evaluation of the sensitization potential, conducted using the local lymph node assay (LLNA) at concentrations ranging from 50% to 100%, identified a dose-dependent increase in lymphocyte proliferation with a calculated EC3 value of 53.1%. While no elevations in total or specific IgE were observed after exposure to any concentration of the chemical, significant increases in IFN-y protein production by stimulated draining lymphoid cells were observed, indicating a T-cell-mediated response. Dermal exposure to PCBTF was not found to alter the immune response to a T-cell-dependant antigen. These results demonstrate that PCBTF has the potential to induce allergic sensitization following dermal exposure and based on LLNA results would be classified as a weak sensitizer. [Description provided by NIOSH]
• Subjects:
  Blood Chemistry Environmental Monitoring Hazardous Substances Hypersensitivity Immune System Occupational Health Risk Assessment Risk Factors Safety Skin Workplace

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• Keywords:
  Chemical-hypersensitivity Chemical-properties Exposure-assessment Exposure-levels Immune-reaction Immune-system-disorders Immunologic-disorders Immunotoxins Lymphocytes Quantitative-analysis Risk-analysis Risk-factors Safety-education Skin-exposure Statistical-analysis Toxic-effects Work-environment Workplace-studies

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• ISSN:
  1687-9783
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  2011
• NIOSHTIC Number:
  nn:20038982
• Citation:
  J Allergy 2011 Mar; 2011:238513
• Contact Point Address:
  Jennifer Franko, Health Effects Laboratory Division, National Institute for Occupational Safety and Health (NIOSH), 1095 Willowdale Drive, Morgantown, WV 26505-2888
• Email:
  hfy0@cdc.gov
• CAS Registry Number:
  1-Chloro-4-(trifluoromethyl)benzene (CAS RN 98-56-6)
• Federal Fiscal Year:
  2011
• Performing Organization:
  West Virginia University
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Allergy
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:752588d01b34d40192d3e7b2a4f3cfb2ffb489d344e403241d6e2eede8b9988ad10cfda5ff5d8eb5782d4b0d3c109245b9802dd3fca47051136ea5f04ceef345
• Download URL:
  https://stacks.cdc.gov/view/cdc/192488/cdc_192488_DS1.pdf
• File Type:
  [PDF - 645.69 KB ]