Carbon nanotube risk assessment: implications for exposure and medical monitoring

Details

• Personal Author:
  Kuempel, Eileen D.
• Description:
  Objective: Quantitative risk estimates using toxicology data provide information for risk management to protect workers with potential exposure to carbon nanotubes (CNTs). Methods: Dose-response data from subchronic inhalation studies in rats were used in benchmark dose modeling. Dose was airborne mass concentration of multiwalled CNTs. Responses included pulmonary inflammation, lipoproteinosis, and fibrosis. Results: Estimated human-equivalent concentrations to the rat lowest observed adverse effect levels were similar to some workplace airborne concentrations of CNTs. Working lifetime risk estimates of early-stage adverse lung effects were more than 10 percent at the limit of quantification (7 microg/m3) of the National Institute for Occupational Safety and Health analytical method for measuring CNT airborne concentrations. Conclusions: Exposure monitoring and control are the primary occupational health measures to protect workers from potential exposure to CNT. Medical monitoring for early detection of occupational respiratory diseases may also be warranted. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Environmental Monitoring Fibrosis Hazardous Substances Health Care Facilities Workforce And Services Lipids Lung Lung Diseases Occupational Exposure Occupational Health Particulate Matter Respiratory System Respiratory Tract Diseases Risk Assessment Safety Toxicology

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• Keywords:
  Airborne-fibers Airborne-particles Analytical-Method Biological-effects Biological-monitoring Control-methods Dose-response Employee-exposure Employee-health Environmental-control Exposure-assessment Hazardous-materials Inhalation-studies Lung-disorders Lung-fibrosis Mathematical-models Medical-monitoring Nanotechnology Nanotubes Protein-biochemistry Pulmonary-system-disorders Quantitative-analysis Respiratory-system-disorders Risk-analysis Toxic-dose Toxic-effects Toxic-materials

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• ISSN:
  1076-2752
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; Ohio ; OSHA Region 5 ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  EID - Education and Information Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  53
• NIOSHTIC Number:
  nn:20038931
• Citation:
  J Occup Environ Med 2011 Jun; 53(6S):S91-S97
• Contact Point Address:
  Eileen D. Kuempel, PhD, Education and Information Division, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, M.S. C-15, Cincinnati, OH 45226
• Email:
  ekuempel@cdc.gov
• CAS Registry Number:
  Carbon (CAS RN 7440-44-0)
• Federal Fiscal Year:
  2011
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• Supplement:
  6S
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:836567dfc556ba660002ce31c172b3b7bd5709a182ac08cff883cca776c2d8aef7d5215010f19c6614ab19d66ed6c9aa4f41689ca8002fe0f3fad1c04281ef6c
• Download URL:
  https://stacks.cdc.gov/view/cdc/192457/cdc_192457_DS1.pdf
• File Type:
  [PDF - 268.17 KB ]