C-reactive protein, interleukin-6, and posttraumatic stress disorder symptomology in urban police officers

Details

• Personal Author:
  Andrew, Michael E. ; Araia SK ; Burchfiel CM ; Joseph PN ; McCanlies EC ; Mnatsakanova A ; Violanti JM
• Description:
  Our aim was to examine the relationship between the level of the inflammatory markers, C-reactive protein (CRP) and interleukin-6 (IL-6), and posttraumatic stress disorder (PTSD) symptomology in a random sample of 115 police officers. CRP was measured in citrated plasma using a particle enhanced immunonepholometric assay and IL-6 was measured in serum with a solid-phase quantitative sandwich ELISA. The presence of high PTSD symptomology was defined as having an Impact of Event Scale score (IES) of ≥26 compared to<26 (low PTSD symptomology). 28% of the officers had high PTSD symptomology. Mean levels of CRP and IL-6 did not differ significantly between officers with high PTSD symptomology and those with low symptomology (CRP: 0.76 mg/l vs. 0.97 mg/l; IL-6: 2.03 pg/ml vs. 1.74 pg/ml). We found no association of CRP and IL-6 levels with PTSD symptomology. This study was limited by sample size and its cross-sectional study design. A lack of association may occur if either CRP or IL-6 is elevated only at the onset of PTSD symptomology, or if inflammation is related to specific key components that define PTSD. Further research examining these relationships in a larger population may be worthwhile. [Description provided by NIOSH]
• Subjects:
  Biological Assay Cytology Immune System Law Enforcement Occupational Health Safety Stress, Psychological
• Keywords:
  Author Keywords: Police BCOPS Bioassays C-reactive Protein (CRP) Immune System Immunochemistry Inflammatory Markers Interleukin-6 (IL-6) Job Stress Law Enforcement Police Officers Post-traumatic Stress Disorder Posttraumatic Stress Disorder (PTSD) PTSD

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• ISSN:
  1043-4666
• Document Type:
  Text
• Funding:
  Contract ; Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2 ; OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  74-78
• Volume:
  55
• Issue:
  1
• NIOSHTIC Number:
  nn:20038684
• Citation:
  Cytokine 2011 Jul; 55(1):74-78
• Contact Point Address:
  Erin C. McCanlies, NIOSH/CDC, 1095 Willowdale Road, M/S 4050, Morgantown, WV 26505, USA
• Email:
  eim4@cdc.gov
• Federal Fiscal Year:
  2011
• NORA Priority Area:
  Services ; Public Safety
• Performing Organization:
  University of New York at Buffalo
• Peer Reviewed:
  False
• Start Date:
  19980930
• Source Full Name:
  Cytokine
• End Date:
  20000929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8363f00cec781ac434f3cce69d9106df96184d938937b79860cee0c4256ce698996eb4a6d602de385a1dc41631f32fceca257c42c011d617fbbf84f0f51125ec
• Download URL:
  https://stacks.cdc.gov/view/cdc/192313/cdc_192313_DS1.pdf
• File Type:
  [PDF - 235.99 KB ]