Risk factors for oligodendroglial tumors: a pooled international study

Details

• Personal Author:
  Aldape K ; Bondy ML ; Brännström T ; Broholm H ; Butler MA ; Davis FG ; Feychting M ; Il'yasova D ; Inskip PD ; Johansen C ; McCarthy BJ ; Melin BS ; Rankin KM ; Ruder, Avima M. ; Scheurer ME ; Schüz J ; Schwartzbaum JA ; Wrensch MR
• Description:
  Oligodendroglial tumors are rare subtypes of brain tumors and are often combined with other glial tumors in epidemiological analyses. However, different demographic associations and clinical characteristics suggest potentially different risk factors. The purpose of this study was to investigate possible risk factors for oligodendroglial tumors (including oligodendroglioma, anaplastic oligodendroglioma, and mixed glioma). Data from 7 case-control studies (5 US and 2 Scandinavian) were pooled. Unconditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs), adjusted for age group, gender, and study site. Data on 617 cases and 1260 controls were available for analyses. Using data from all 7 studies, history of allergies and/or asthma was associated with a decreased risk of anaplastic oligodendroglioma (OR = 0.6; 95% CI: 0.4-0.9), and history of asthma only was associated with a decreased risk of oligodendroglioma (OR = 0.5; 95% CI: 0.3-0.9) and anaplastic oligodendroglioma (OR = 0.3; 95% CI: 0.1-0.9). A family history of brain tumors was associated with an increased risk of anaplastic oligodendroglioma (OR = 2.2; 95% CI: 1.1-4.5). Having had chicken pox was associated with a decreased risk of oligodendroglioma (OR = 0.6; 95% CI: 0.4-0.9) and anaplastic oligodendroglioma (OR = 0.5; 95% CI: 0.3-0.9) in the US studies. Although there is some overlap in risk factors between oligodendroglial tumors and gliomas as a group, it is likely that additional factors specific to oligodendroglial tumors have yet to be identified. Large, multi-institution international studies will be necessary to better characterize these etiological risk factors. [Description provided by NIOSH]
• Subjects:
  Epidemiology Neoplasms Nervous System Nervous System Diseases Nervous System Disorders Occupational Health Risk Assessment Safety
• Keywords:
  Author Keywords: Anaplastic Oligodendroglioma Brain-disorders Cancer Central-nervous-system-disorders Mixed Gliomaoligodendroglioma Risk-analysis Risk Factors Statistical-analysis Tumors
• ISSN:
  1522-8517
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  California ; Illinois ; Maryland ; North Carolina ; Ohio ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 6 ; OSHA Region 9 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  242-250
• Volume:
  13
• Issue:
  2
• NIOSHTIC Number:
  nn:20038262
• Citation:
  Neuro-Oncology 2011 Feb; 13(2):242-250
• Contact Point Address:
  Bridget J. McCarthy, PhD, Department of Epidemiology/Biostatistics, School of Public Health, University of Illinois at Chicago, 1603 W. Taylor St. (M/C 923), Chicago, IL 60612
• Email:
  bjm3@uic.edu
• Federal Fiscal Year:
  2011
• NORA Priority Area:
  Agriculture, Forestry and Fishing ; Services
• Peer Reviewed:
  True
• Source Full Name:
  Neuro-Oncology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d0f08bd828993d5dba5034b55125ded474015a50b8ab19f73f1f87c3baf3fa64356de0f2fafdfeafe1e953562de20e1e9579a26793399f9f06440531e188d4a7
• Download URL:
  https://stacks.cdc.gov/view/cdc/192028/cdc_192028_DS1.pdf
• File Type:
  [PDF - 126.13 KB ]