Cerium oxide nanoparticle-induced pulmonary inflammation and alveolar macrophage functional change in rats

Details

• Personal Author:
  Barger M ; Castranova, Vincent ; Ma JK ; Ma JY ; Meighan T ; Mercer RR ; Rao M ; Schwegler-Berry D ; Zhao H ; Barger M ; Castranova, Vincent ; Ma JK ; Ma JY ; Meighan T ; Mercer RR ; Rao M ; Schwegler-Berry D ; Zhao H
• Description:
  The use of cerium compounds as diesel fuel catalyst results in the emission of cerium oxide nanoparticles (CeO2) in the exhaust. This study characterized the potential effects of CeO2 exposure on lung toxicity. Male Sprague Dawley rats were exposed to CeO2 by a single intratracheal instillation at 0.15, 0.5, 1, 3.5 or 7 mg/kg body weight. At 1 day after exposure, CeO2 significantly reduced NO production, but increased IL-12 production, by alveolar macrophages (AM) in response to ex vivo lipopolysacchride (LPS) challenge, and caused AMapoptosis, through activation of caspases 9 and 3. CeO2 exposure markedly increased suppressor of cytokine signaling-1 at 1-day and elevated arginase-1 at 28-day post exposure in lung cells, while osteopontin was significantly elevated in lung tissue at both time points. CeO2 induced inflammation, cytotoxicity, air/blood barrier damage, and phospholipidosis with enlarged AM. Thus, CeO2 induced lung inflammation and injury in lungs which may lead to fibrosis. [Description provided by NIOSH]
• Subjects:
  Animals Cytotoxins Environmental Monitoring Irritants Laboratories Lipids Lung Lung Diseases Nitrogen Oxides Occupational Health Respiratory System Respiratory Tract Diseases Safety Vehicle Emissions

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• Keywords:
  Alveolar-cells Alveolar Macrophages Animal-studies Author Keywords: Cerium Oxide Cerium-compounds Cytotoxic-effects Diesel-emissions Diesel-exhausts Exposure-assessment Genotoxic-effects Laboratory-animals Lung-cells Lung-disorders Lung-fibrosis Lung-irritants Lung Injury Nanoparticle Nanotechnology Nitrogen-oxides Phospholipids Polysaccharides Pulmonary-function Pulmonary-system Pulmonary-system-disorders Pulmonary Fibrosis Respiratory-irritants

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• ISSN:
  0957-4484
• Document Type:
  Text
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  312-325
• Volume:
  5
• Issue:
  3
• NIOSHTIC Number:
  nn:20038116
• Citation:
  Nanotechnology 2011 Sep; 5(3):312-325
• Contact Point Address:
  Dr Jane Y. C.Ma, PhD, PPRB/HELD, NIOSH, 1095Willowdale Road, Morgantown, West Virginia 26505-2888, USA
• Email:
  jym1@cdc.gov
• CAS Registry Number:
  Ceria (CAS RN 1306-38-3) ; Ceria (CAS RN 1306-38-3)
• Federal Fiscal Year:
  2011
• NORA Priority Area:
  Transportation, Warehousing and Utilities ; Transportation, Warehousing and Utilities
• Peer Reviewed:
  True
• Source Full Name:
  Nanotechnology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:552747c9e1389888f8270e9a48736def931732fe796b0a3e32c3eb246a4046a9bdf36eaffb401fd6cc4b82fea09dd68fe18174436edd3f8df73d88a1bbc442c7
• Download URL:
  https://stacks.cdc.gov/view/cdc/191925/cdc_191925_DS1.pdf
• File Type:
  [PDF - 872.62 KB ]