Associations of patella lead with polymorphisms in the vitamin D receptor, delta-aminolevulinic acid dehydratase and endothelial nitric oxide synthase genes

Details

• Personal Author:
  Kelsey KT ; Lee BK ; Lustberg ME ; Parsons PJ ; Schwartz BS ; Silbergeld EK ; Theppeang K ; Todd AC
• Description:
  A cross-sectional analysis was performed to evaluate associations of polymorphisms in the vitamin D receptor (VDR), delta-aminolevulinic acid dehydratase (ALAD), and endothelial nitric oxide synthase (eNOS) genes with patella lead concentrations in 652 lead workers in the Republic of Korea. There was a wide range of patella lead (from below detection limit to 946 microg Pb/g bone mineral), with a mean (standard deviation) of 75.2 (101.0). There were no associations of ALAD or eNOS genotypes with patella lead, but workers with the VDR B allele had significantly (P value < 0.05) higher patella lead (on average, 25% or approximately 6.6 microg Pb/g bone mineral) than lead workers with the VDR bb genotype. There was evidence that the relation between age and patella lead was modified by both the VDR and eNOS genotypes. [Description provided by NIOSH]
• Subjects:
  Age Factors Biomarkers Blood Hematologic Tests Lead Men Musculoskeletal System Occupational Exposure Occupational Health Safety Women

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• Keywords:
  Age-factors Blood-analysis Blood-cells Bone-structure Exposure-levels Exposure-limits Humans Lead-absorption Occupational-hazards Occupational-health Workers

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• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; Massachusetts ; New York ; OSHA Region 1 ; OSHA Region 2 ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  46
• Issue:
  6
• NIOSHTIC Number:
  nn:20038079
• Citation:
  J Occup Environ Med 2004 Jun; 46(6):528-537
• Contact Point Address:
  Andrew C. Todd, PhD, The Mount Sinai School of Medicine, Department of Community and Preventive Medicine, 1 Gustave L. Levy Place, Box 1057, New York, NY 10029
• Email:
  andrew.todd@mssm.edu
• CAS Registry Number:
  Lead (CAS RN 7439-92-1)
• Federal Fiscal Year:
  2004
• Performing Organization:
  Johns Hopkins University
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6bc68afa0a6621ca8e69b56bdbc3adc329b064e97cc2bafbf6f4b3e28af61481a2297431c573e71751fb504410026fb4e5bfb1573b098a174fffc87df4ef8454
• Download URL:
  https://stacks.cdc.gov/view/cdc/191899/cdc_191899_DS1.pdf
• File Type:
  [PDF - 248.64 KB ]