Model-based time extrapolation for quantal response studies

Details

• Personal Author:
  Bailer AJ ; Smith RJ
• Description:
  It is often desired to compare chemicals with respect to toxicity for purposes of priority setting in regulation. Long-term carcinogenicity studies are frequently used as the basic data for such exercises. When the results of these studies for different chemicals are compared, many confounders potentially arise. One confounder is that these studies may have been conducted for different study lengths. In this case, converting the results of these studies to a common "standard" time length would be of interest. We propose an adjustment to modify the results of a study with a particular study length to a standard time length. This adjustment is based on a simple stochastic model for carcinogenicity studies. We illustrate the application of this adjustment with an example of a chemical that has been studied by the National Toxicology Program. [Description provided by NIOSH]
• Subjects:
  Carcinogens Longevity Occupational Health Risk Assessment Safety
• Keywords:
  Biostatistics Carcinogenicity Lifespan Long-term-study Mathematical-models Risk-analysis Standards Statistical-analysis Time-weighted-average-exposure
• ISSN:
  0006-341X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSDTT - Division of Standards Development and Technology Transfer
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  220-225
• Volume:
  50
• Issue:
  1
• NIOSHTIC Number:
  nn:20037765
• Citation:
  Biometrics 1994 Mar; 50(1):220-225
• Federal Fiscal Year:
  1994
• Peer Reviewed:
  True
• Source Full Name:
  Biometrics
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b505f2d74384ee5b50b02051ac5c01cbdf085df8168a75aa97f33a95255963bb4ebbf29de53d368afce96b5f3bdc914ae481f1029b5f432683b22196eb4cc892
• Download URL:
  https://stacks.cdc.gov/view/cdc/191749/cdc_191749_DS1.pdf
• File Type:
  [PDF - 604.01 KB ]