Matrix metalloproteinases, IL-8 and glutathione in the prognosis of workers exposed to chlorine

Details

• Personal Author:
  Castellanos L ; Gautrin D ; L'Archevêque J ; Maghni K ; Malo JL
• Description:
  BACKGROUND: Workers exposed to chlorine may be at risk of deterioration in FEV1. METHODS: A prospective study of 72 workers examined over a 5.8 +/- 1.9 year period. A sample of induced sputum for cells and mediators was obtained in 69 subjects at baseline (Vb) and in 36 both at Vb and at follow-up (Vf). RESULTS: Sixty-four workers (89%) experienced at least one accidental inhalation of chlorine in the interval. The mean decrease in FEV1 was 30 ml/year and thus was within normal limits. Among the analysed remodelling markers, the level of the MMP-9-TIMP-1 complex, but not of free MMP-9 and TIMP-1, significantly diminished from Vb to Vf. We found significant correlations between neutrophils, IL-8, MMP-9 and MMP9-TIMP-1 complex at Vb and Vf. While levels of total glutathione, IL-8, MMP9, TIMP-1 and MMP9-TIMP-1 complex were highly correlated with each other at Vb, this was inconstant at Vf. Levels of MMP9-TIMP1 complex and of TIMP1 at Vf were significantly lower in workers reporting chlorine puffs with mild acute respiratory symptoms between visits compared to those who had no, or asymptomatic inhalations (P = 0.03 and 0.02, respectively). The fall in FEV1 from Vb to Vf was significantly correlated with levels of glutathione at Vb. Cough between visits was associated with a decrease in FEV1 (P = 0.06). CONCLUSION: Although no accelerated loss in FEV1 was documented in these workers exposed to chlorine, subjects with a greater fall in FEV1 were more likely to report cough and have higher levels of total glutathione at Vb. [Description provided by NIOSH]
• Subjects:
  Accidents, Occupational Chlorine Compounds Environmental Monitoring Hypersensitivity Irritants Occupational Exposure Occupational Health Respiratory Function Tests Respiratory Hypersensitivity Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Accident-rates Accident-statistics Airway-obstruction Author Keywords: Irritant-induced Asthma Chemical-hypersensitivity Chlorine-compounds Dose-response Exposure-assessment Exposure-levels Exposure-methods Inhalation-studies Occupational-exposure Occupational-hazards Occupational-health Occupational Asthma Pulmonary-system-disorders Reactive Airways Dysfunction Syndrome Respiratory-function-tests Respiratory-hypersensitivity Respiratory-irritants Statistical-analysis

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• ISSN:
  0105-4538
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  65
• Issue:
  6
• NIOSHTIC Number:
  nn:20037761
• Citation:
  Allergy 2010 Jun; 65(6):722-730
• Contact Point Address:
  Jean-Luc Malo, MD, Department of Chest Medicine, Hospital du Sacre-Coeur, 5400 West Gouin Blvd, Montreal, QC, Canada H4J 1C5
• CAS Registry Number:
  Chlorine (CAS RN 7782-50-5) ; Glutathione (CAS RN 70-18-8)
• Federal Fiscal Year:
  2010
• NORA Priority Area:
  Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease
• Performing Organization:
  Hospital du Sacre-Coeur, Montreal, Quebec
• Peer Reviewed:
  True
• Start Date:
  19990930
• Source Full Name:
  Allergy
• End Date:
  20021229
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5613774d377571d15ff45b4efcd11ac0c510b83e726576d3bd685930862fb8b07241719c1d7bc91d6d9163e884944f54f4bc84172c87c34e673e55b304491528
• Download URL:
  https://stacks.cdc.gov/view/cdc/191746/cdc_191746_DS1.pdf
• File Type:
  [PDF - 167.37 KB ]