The occupational contribution to severe exacerbation of asthma

Details

• Personal Author:
  Antó JM ; Dahlman-Höglund A ; Henneberger, Paul K. ; Jarvis DL ; Kogevinas M ; Kromhout H ; Lillienberg L ; Mirabelli MC ; Norbäck D ; Olivieri M ; Plana E ; Radon K ; Torén, Kjell ; Urrutia I ; Villani S ; Zock JP
• Description:
  The goal of this study was to identify occupational risk factors for severe exacerbation of asthma and estimate the extent to which occupation contributes to these events. The 966 participants were working adults with current asthma who participated in the follow-up phase of the European Community Respiratory Health Survey. Severe exacerbation of asthma was defined as self-reported unplanned care for asthma in the past 12 months. Occupations held in the same period were combined with a general population job-exposure matrix to assess occupational exposures. 74 participants reported having had at least one severe exacerbation event, for a 1-yr cumulative incidence of 7.7%. From regression models that controlled for confounders, the relative risk (RR) was statistically significant for low (RR 1.7, 95% CI 1.1-2.6) and high (RR 3.6, 95% CI 2.2-5.8) biological dust exposure, high mineral dust exposure (RR 1.8, 95% CI 1.02-3.2), and high gas and fumes exposure (RR 2.5, 95% CI 1.2-5.5). The summary category of high dust, gas, or fumes exposure had RR 3.1 (95% CI 1.9-5.1). Based on this RR, the population attributable risk was 14.7% among workers with current asthma. These results suggest occupation contributes to approximately one in seven cases of severe exacerbation of asthma in a working population, and various agents play a role. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Asthma Asthma, Occupational Inhalation Exposure Lung Occupational Health Particulate Matter Respiratory Hypersensitivity Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Author Keywords: Asthma Bronchial-asthma Exacerbation Exposure-limits Fumes Inhalants Occupational Particulates Pulmonary-function Pulmonary-system Pulmonary-system-disorders Respiratory-hypersensitivity Respiratory-system-disorders Work-related

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• ISSN:
  0903-1936
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  36
• Issue:
  4
• NIOSHTIC Number:
  nn:20037755
• Citation:
  Eur Respir J 2010 Oct; 36(4):743-750
• Contact Point Address:
  P.K. Henneberger, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, MS H2800, 1095 Willowdale Road, Morgantown, WV 26505, USA
• Email:
  pkh0@cdc.gov
• Federal Fiscal Year:
  2011
• Peer Reviewed:
  True
• Source Full Name:
  European Respiratory Journal
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:19237f4f1bd0604d984e4358b941cdc4e78749fa59b9f4b3240e0106130a45943ef94095b7c616326ebae482736d58efdf9cbf42f41c98bb8a2294cf25eef1d3
• Download URL:
  https://stacks.cdc.gov/view/cdc/191741/cdc_191741_DS1.pdf
• File Type:
  [PDF - 341.65 KB ]