Allergic contact dermatitis to synthetic rubber gloves: changing trends in patch test reactions to accelerators

Details

• Personal Author:
  Cao LY ; Murray D ; Siegel, Paul D. ; Sood A ; Taylor JS ; Cao LY ; Murray D ; Siegel, Paul D. ; Sood A ; Taylor JS
• Description:
  Background: Rubber gloves are one of the most frequent causes of occupational allergic contact dermatitis, especially in health care workers. Observations: We describe 23 patients with allergic contact dermatitis due to rubber accelerators in rubber gloves, some with disseminated dermatitis, treated during a 2-year period. Three had IgE-mediated latex allergies. Sixteen were health care workers from a single institution whose dermatitis was temporally related to the switch to latex-safe gloves. Each had positive patch test reactions to 1 or more rubber accelerators, including carbamates, thiurams, 2-mercaptobenzothiazole, and 1,3-diphenylguanidine. Chemical analysis of 6 glove samples identified 2-mercaptobenzothiazole in 4 and zinc diethyldithiocarbamate in 1. There were discordances between patch test results for glove chemicals and glove swatches and between available information on chemicals used during glove production and chemicals detected during glove analysis. Although these factors may complicate the search for culprit and alternative gloves, dermatitis cleared in each of 9 patients with follow-up data and for whom alternative gloves were provided based on published information of glove composition. Conclusions: Allergic contact dermatitis due to synthetic rubber gloves occurs even with the use of latex-safe products. More knowledge about chemicals present in these gloves, to which the skin is exposed during use, is necessary to prevent and treat allergic contact dermatitis. [Description provided by NIOSH]
• Subjects:
  Carbamates Dermatitis Health Personnel Hypersensitivity Occupational Health Personal Protective Equipment Safety Skin Skin Diseases Sulfhydryl Compounds Zinc Compounds

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• Keywords:
  Allergic-dermatitis Allergic-reactions Allergies Alternatives Author Keywords: Health-Care Workers Chemical-hypersensitivity Chemicals Cross-Sectional Data Frequency Gloves Guanidines Health-care-personnel IV Allergy Latex Allergy Mercaptans Occupation Patch-tests Prevalence Protective Gloves Skin-exposure Skin-sensitivity Synthetic-rubbers Thiazoles Thiuram-compounds Zinc-compounds

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• ISSN:
  0003-987X
• Document Type:
  Text
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  Ohio ; OSHA Region 3 ; OSHA Region 5 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Volume:
  146
• Issue:
  9
• NIOSHTIC Number:
  nn:20037735
• Citation:
  Arch Dermatol 2010 Sep; 146(9):1001-1007
• Contact Point Address:
  James S. Taylor, MD, A-61, Department of Dermatology, Dermatology-Plastic Surgery Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195
• Email:
  taylorj@ccf.org
• CAS Registry Number:
  2-Mercaptobenzothiazole (CAS RN 149-30-4) ; Diphenylguanidine (CAS RN 102-06-7) ; Ziram (CAS RN 137-30-4) ; 2-Mercaptobenzothiazole (CAS RN 149-30-4) ; Diphenylguanidine (CAS RN 102-06-7) ; Ziram (CAS RN 137-30-4)
• Federal Fiscal Year:
  2010
• NORA Priority Area:
  Healthcare and Social Assistance ; Healthcare and Social Assistance
• Peer Reviewed:
  True
• Source Full Name:
  Archives of Dermatology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ae956d53b44b7c593e2199370c5cea02978fb0046acc8a9be23b5a80f8ff467e02662b42342fac0cf50efa61847153aed3f9a6557dff3cb05b181e6aa365a0c1
• Download URL:
  https://stacks.cdc.gov/view/cdc/191722/cdc_191722_DS1.pdf
• File Type:
  [PDF - 96.13 KB ]