Proapoptotic Factor Bax Is Increased in Satellite Cells in the Tibialis Anterior Muscles of Old Rats

Details

• Personal Author:
  Alway SE ; Baker B ; Cutlip, Robert G. ; Geronilla K ; Krajnak, Kristine M. ; Miller R ; Waugh, Stacey
• Description:
  Aging impairs the ability of muscle to adapt to exercise or injury. The goal of this study was to determine whether age-related changes in muscle adaptability could be the result of satellite cell apoptosis. Ten days after exposure to an injury protocol, estimates of edema in the exposed tibialis anterior muscles were higher in old (30 months) than young (3 months) rats, and isometric force levels were lower in old rats. Both young and old rats displayed an increase in MyoD labeling in the exposed muscle, indicating that injury induced satellite-cell activation. However, there were more MyoD-labeled cells that coexpressed the proapoptotic factor, Bax, in old than in young rats, suggesting that decrements in muscle recovery may be associated with an increase in satellite-cell apoptosis. Based on these findings we conclude that reducing satellite-cell apoptosis in aged animals may improve muscle recovery after injury. [Description provided by NIOSH]
• Subjects:
  Animals Environmental Monitoring Laboratories Musculoskeletal System Occupational Health Safety
• Keywords:
  Animal-studies Exposure-assessment Exposure-levels Injuries Laboratory-animals Muscle-cells Muscle-contraction Muscles
• ISSN:
  0148-639X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  34
• Issue:
  6
• NIOSHTIC Number:
  nn:20031363
• Citation:
  Muscle Nerve 2006 Dec; 34(6):720-730
• Contact Point Address:
  Kristine Krajnak, Engineering and Controls Technology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., MS 2027, Morgantown, West Virginia 26505, USA
• Email:
  ksk1@cdc.gov
• Federal Fiscal Year:
  2007
• NORA Priority Area:
  Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
• Peer Reviewed:
  True
• Source Full Name:
  Muscle & Nerve
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:145472839070a6c88faa93104b24aa467cee79850fc7f15674bcb4bd71b3501b99e7669eb2c13017067214458e1deef592d479bfa0b54331c44e712603f4aabd
• Download URL:
  https://stacks.cdc.gov/view/cdc/191628/cdc_191628_DS1.pdf
• File Type:
  [PDF - 476.10 KB ]